Anti-TFPI Antibody

Cat: 50131-RP01
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All TFPI Reagents
Anti-TFPI Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-TFPI Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse TFPI
Recombinant Mouse TFPI protein (Catalog#50131-M08H)
Produced in rabbits immunized with purified, recombinant Mouse TFPI / LACI (rM TFPI; Catalog#50131-M08H; NP_006278.1; Met 1-Lys 282). Total IgG was purified by Protein A affinity chromatography .
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TFPI Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TFPI Antibody Alternative Names
Anti-A630013F22Rik Antibody;Anti-AW552122 Antibody;Anti-EPI Antibody;Anti-LACI Antibody
TFPI Background Information

Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease. In a factor (F) Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex. Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms. TFPI also circulates in complex with plasma lipoproteins. The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF. TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases. In addition, Studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo. In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis.

Full Name
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
  • Lwaleed BA, et al. (2006) Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 208(3): 327-39.
  • Amirkhosravi A, et al. (2007) The role of tissue factor pathway inhibitor in tumor growth and metastasis. Semin Thromb Hemost. 33(7): 643-52.
  • Maroney SA, et al. (2008) Expression of tissue factor pathway inhibitor by endothelial cells and platelets. Transfus Apher Sci. 38(1): 9-14.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TFPI Antibody Rabbit Monoclonal ELISA 50131-R120
    Anti-TFPI Antibody Rabbit Monoclonal ELISA(Cap) 50131-R004
    Anti-TFPI Antibody Rabbit Polyclonal ELISA 50131-T16
    Anti-TFPI Antibody Rabbit Monoclonal ELISA(Det) 50131-R103
    Anti-TFPI Antibody Rabbit Monoclonal ELISA 50131-R107
    Anti-TFPI Antibody Rabbit Monoclonal ELISA(Det),IHC-P,ICC/IF,IF 10564-R401
    Anti-TFPI Antibody Rabbit Polyclonal ELISA 10564-RP02
    Anti-TFPI Antibody Mouse Monoclonal ELISA(Cap) 10564-MM02
    Anti-TFPI Antibody Rabbit Monoclonal ELISA 10564-R003
    Anti-TFPI Antibody Rabbit Monoclonal WB,IP 10564-R006
    Anti-TFPI Antibody Mouse Monoclonal ELISA 10564-MM01
    Anti-TFPI Antibody Rabbit Polyclonal ELISA 10564-RP01
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