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Human TETHERIN / BST2 / CD317 Protein (Fc Tag)
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Human TETHERIN / BST2 / CD317 Protein (Fc Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
13370-H01H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Bone marrow stromal cell antigen 2 Protein Datasheet

 

TETHERIN / BST2 / CD317 Protein Price Inquiry ( Available Sizes )

TETHERIN / BST2 / CD317 Protein Product Information

Synonym : BST2
Protein Construction:

A DNA sequence encoding the human BST2(Q10589) (Asn49-Ser160) was expressed ,with the fused Fc region of human IgG1 at the N-terminus.

Source: Human
Expression Host: Human Cells

TETHERIN / BST2 / CD317 Protein QC Testing

Purity: > 90 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

TETHERIN / BST2 / CD317 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Glu
Molecular Mass:

The recombinant human BST2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 372 amino acids and has a predicted molecular mass of 41 kDa. The apparent molecular mass of the protein is approximately 51 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

TETHERIN / BST2 / CD317 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TETHERIN / BST2 / CD317 Protein Related Products & Topics

Related Areas:

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>BST2/CD317

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BST2 Human TETHERIN / BST2 / CD317 Protein, Recombinant 13370-H01H
BST2 Human TETHERIN / BST2 / CD317 Protein, Recombinant 13370-H07H
BST2 Mouse BST2 Protein, Recombinant 51043-M01H

Antibodies:

TETHERIN / BST2 / CD317 Protein Description

Tetherin also known as bone marrow stromal antigen 2 and BST2 is single-pass type Ⅱ membrane protein with an extracellular coiled coil domain forms a long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading. BST2 predominantly expressed in liver, lung, heart and placenta and low levels in pancreas, kidney, skeletal muscle and brain. This protein is found overexpressed in multiple myeloma cells. It is highly expressed during B-cell development, from pro-B precursors to plasma cells, and on T-cells, monocytes, NK cells and dendritic cells. BST2 is involved in the sorting of secreted proteins and in pre-B cell growth. As an antiretroviral defense protein, BST2 blocks release of enveloped virus from the cell surface. Active against at least four virus families: retroviruses, filoviruses, arenaviruses, and herpesviruses. BST2 is discovered as an inhibitor to HIV-1 infection in the absence of Vpu and it inhibits the release of other viruses such as the Lassa and Marburg virions.

References

  1. Ishikawa J. et al., 1995, Genomics. 26 (3): 527-34.
  2. Viswanathan K. et al., 2011, PLoS Pathog. 7 (11): 10023-32.
  3. Gifford RJ. 2011, Hum Mutat. 32 (11).
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"