TACI / TNFRSF13B Protein (CD267 Protein)

Transmembrane activator and CAML interactor / Tumor necrosis factor receptor superfamily, member 13B (Cluster of Differentiation 267)

TACI / TNFRSF13B Products

TACI / TNFRSF13B Protein, Recombinant

Molecule	Species	Description	Cat. No
TACI/TNFRSF13B	Human	TACI/TNFRSF13B Protein, Recombinant	11937-H08H

TACI / TNFRSF13B cDNA Clone

Molecule	Species	Description	Cat. No
TACI/TNFRSF13B	Mouse	Mouse TACI/TNFRSF13B cDNA Clone / ORF Clone	MG50130-M
TACI/TNFRSF13B	Rat	Rat TACI/TNFRSF13B cDNA Clone / ORF Clone	RG80157-G

TACI / TNFRSF13B Related Areas

Immunology>>Adaptive Immunity >>B Cell>>TACI/TNFRSF13B

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>TACI/TNFRSF13B

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>TACI/TNFRSF13B/CD267

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TACI/TNFRSF13B

TACI / TNFRSF13B Alternative Names

TACI, TNFRSF13B, CD267, CVID, CVID2, FLJ39942, MGC133214, MGC39952, TNFRSF14B [Homo sapiens]

Taci, Tnfrsf13b, RP23-55I2.2, 1200009E08Rik [Mus musculus]

TACI / TNFRSF13B Background

Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF13B is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. TACI/TNFRSF13B/CD267 induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand.

TACI / TNFRSF13B Related Studies

1. Salzer U, et al. (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet. 37(8): 820-8.
2. Salzer U, et al. (2009) Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood. 113(9): 1967-76.
3. Mohammadi J, et al. (2009) Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency. J Clin Immunol. 29(6): 777-85.