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> T Cell Migration/Adhesion T Cell Migration/Adhesion
Sino biological offers a wide selection of tools research on T cell migration/adhesion, including
| Product Categories / Species | Human | Mouse | Rat |
| Recombinant Proteins | 32 | 17 | 2 |
| Antibodies | 24 | 16 | - |
| ELISA Kit | 3 | - | - |
| ORF cDNA Clones | 21 | 21 | 4 |
T Cell Related Products Index
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T Cell Migration/Adhesion Related Products
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T Cell Migration/Adhesion Background
The ability of T cells to migrate and adhere is critical for a fully functional immune system. T cells are able to migrate along a chemotactic gradient, which enables them to exit the bloodstream and reach different tissues. In vitro T cells are observed to move across the surfaces of antigen presenting cells (APCs) in a state of motility. Motile T cells display a polarized morphology with the leading edge and the uropod. Within the two cellular compartments, chemoattractant receptors, cell-adhesion molecules and cytoskeletal proteins are redistributed during T cell polarization. Specialized microvessels control the migration of T cells from blood into tissues. In most microvascular beds, postcapillary venules interact efficiently with leukocytes, thus minimizing the effects of leukocyte adhesion on gas exchange in capillaries and on tissue perfusion. Flowing blood quickly dislodges cells that touch the vessel wall, because it exerts a shear stress of up to approximately 50 dyn per square centimeter. T cells must engage several sequential adhesion pathways to leave the circulation. An individual T cell makes innumerable intercellular contacts with antigen presenting cells, the vascular endothelium, and many other cell types, a process which is dependent on integrin-mediated adhesion to the endothelium. Endothelial adhesion molecules with a dominant role in tissue-specific migration are often called "vascular addressins"; their counter-receptors on lymphocytes are called "homing receptors." The best understood adhesion cascades mediate homing of naive T cells to lymph nodes and Peyer's patches.
T Cell Migration/Adhesion Related Studies
- Serrador JM, et al. (1999) Cytoskeletal rearrangement during migration and activation of T lymphocytes. Trends Cell Biol. 9(6):228-33.
- von Andrian UH, et al. (2000) T-cell function and migration. Two sides of the same coin. N Engl J Med. 343(14):1020-34.
- Miller MJ, et al. (2003) Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A. 100(5):2604-9.
- Engelhardt B. (2006) Molecular mechanisms involved in T cell migration across the blood-brain barrier. J Neural Transm. 113(4):477-85.
- Cairo CW, et al. (2008) T cell adhesion mechanisms revealed by receptor lateral mobility. Biopolymers. 89(5):409-19.
