T Cell Antigen Recognition

Sino biological offers a wide selection of tools for research on T cell antigen recognition, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones. Antigen recognition is one of the most debated aspects of the immune response and its mechanism is central to most theories of antibody formation. T cell antigen recognition is initiated by the MHC presenting a short peptide sequence which is recognized by T cells expressing a specific T cell receptor (TCR). TCR associates with accessory molecules like CD3, to form the TCR complex that is responsible for T cell antigen recognition.

Product / Species	Human	Mouse	Ferret	Rat
Recombinant Proteins	19	12	1	1
Antibodies	10	12	-	-
ORF cDNA Clones	15	16	-	3

T Cell Antigen Recognition Related Products

• CD1d
• CD45
• Ly9 / CD229 / SLAMF3
• CD3d
• CD80 / B7-1
• SPG21 / ACP33
• CD3e
• CD86 / B7-2
• TIM4
• CD4
• CD278 / ICOS / AILIM
• TLR1 / CD281
• CD6
• Dectin-1 / CLEC7A
• TLR3 / CD283
• CD28
• Lck
• TLR4 / CD284

T Cell Antigen Recognition Background

Antigen recognition is one of the most debated aspects of the immune response and its mechanism is central to most theories of antibody formation. T cells fail to recognize native antigens, but can only recognize processed antigen (antigenic peptides) presented by the major histocompatibility complex (MHC) molecules that are expressed on the surface of the antigen presenting cells (APCs). T cell antigen recognition is initiated by the MHC presenting a short peptide sequence which is recognized by T cells expressing a specific T cell receptor (TCR). The structure of TCR is very similar to immunoglobulin Fab fragments, which are regions defined as the combined light and heavy chain of an antibody arm. T-cell receptors recognize features both of the peptide antigen and of the MHC molecule to which it is bound. This introduces an extra dimension to antigen recognition by T cells, known as MHC restriction, because any given T-cell receptor is specific not simply for a foreign peptide antigen, but for a unique combination of a peptide and a particular MHC molecule. TCR associates with accessory molecules like CD3, to form the TCR complex that is responsible for T cell antigen recognition. Full activation of naïve T cells requires at least two signals. Following the first antigen presenting signal is the costimulation, which is antigen nonspecific and is provided by molecules on APCs that engage particular costimulatory receptors on T cells. Costimulatory molecules stimulate T cells in conjunction with antigen. The ITAM motifs on the CD3 epsilon can be phosphorylated by Lck and in turn recruit ZAP-70. Phosphorylation of the ITAM motifs promotes aggregation of signaling complexes and initiates further signal transduction cascades.

T Cell Antigen Recognition Related Studies

1. Mannie MD. (1991) A unified model for T cell antigen recognition and thymic selection of the T cell repertoire. J Theor Biol. 151(2):169-92.
2. van der Merwe PA. (1999) A subtle role for CD2 in T cell antigen recognition. J Exp Med. 190(10):1371-4.
3. Huppa JB, et al. (2003) T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol. 3(12):973-83.
4. van der Merwe PA, et al. (2003) Molecular interactions mediating T cell antigen recognition. Annu Rev Immunol. 659-84.
5. Ramana CV, et al. (2006) Lung epithelial NF-kappaB and Stat1 signaling in response to CD8+ T cell antigen recognition. J Interferon Cytokine Res. 26(5):318-27.

Related Products

T Cell Antigen Recognition CD Antigen