Syndecan-4 / SDC4 Protein

Syndecan-4 / SDC4 Products

Syndecan-4 / SDC4 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Syndecan-4/SDC4	Mouse	SDC4/Syndecan-4 Protein, Recombinant	50726-M08H

Syndecan-4 / SDC4 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Syndecan-4/SDC4	Human	Human Syndecan-4 Gene cDNA Clone / ORF Clone	HG10653-M
Syndecan-4/SDC4	Human	Human Syndecan-4 / SDC4 ORF Expression Clone, untagged	HG10653-M-N
Syndecan-4/SDC4	Mouse	Mouse Syndecan-4/SDC4 cDNA Clone / ORF Clone	MG50726-G

Syndecan-4 / SDC4 Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Syndecan-4/SDC4

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Syndecan-4/SDC4

Syndecan-4 / SDC4 Alternative Names

Syndecan-4, SDC4, MGC22217, SYND4 [Homo sapiens]

Syndecan-4, Sdc4, RP23-462O16.6, AA959608, AW108331, Synd4, ryudocan [Mus musculus]

Syndecan-4 / SDC4 Background

SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

Syndecan-4 / SDC4 Related Studies

1. Ikesue M, et al. (2011) Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arterioscler Thromb Vasc Biol. 31(5): 1066-74.
2. Saoncella S, et al. (2004) Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent manner. J Biol Chem. 279(45): 47172-6.
3. Bass MD, et al. (2002) Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J. 368(Pt 1): 1-15.
4. Couchman JR, et al. (1999) Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J Cell Sci. 112 ( Pt 20): 3415-20.