All Syndecan-4 reagents are produced in house and quality controlled, including 5 Syndecan-4 Antibody, 26 Syndecan-4 Gene, 1 Syndecan-4 IPKit, 2 Syndecan-4 Lysate, 2 Syndecan-4 Protein, 2 Syndecan-4 qPCR. All Syndecan-4 reagents are ready to use.
Recombinant Syndecan-4 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
Syndecan-4antibodies are validated with different applications, which are ELISA, IHC-P, ICC/IF, IF, FCM, WB, IP.
Syndecan-4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Syndecan-4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.