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Syndecan-4/SDC4 Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells
  • Slide 1
50726-M02H-50
50726-M02H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
50726-M08H-50
50726-M08H-100
50 µg / $178
100 µg / $298
Add to Cart

Syndecan-4/SDC4 Related Areas

Syndecan-4/SDC4 Related Pathways

Syndecan-4/SDC4 Related Product

    Syndecan-4/SDC4 Summary & Protein Information

    Syndecan-4/SDC4 Background

    Gene Summary: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
    General information above from NCBI
    Subunit structure: Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP.
    Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form (By similarity).
    Isoform 2: Secreted.
    Tissue specificity: Expressed in epithelial and fibroblastic cells.
    Post-translational: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
    Sequence similarity: Belongs to the syndecan proteoglycan family.C
    General information above from UniProt

    SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

    Syndecan-4/SDC4 Alternative Name

    MGC22217,SYND4,Syndecan-4,SDC4, [human]
    AA959608,AW108331,ryudocan,RP23-462O16.6,Sdc4,Synd4,Syndecan-4, [mouse]

    Syndecan-4/SDC4 Related Studies

  • Ikesue M, et al. (2011) Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arterioscler Thromb Vasc Biol. 31(5): 1066-74.
  • Saoncella S, et al. (2004) Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent manner. J Biol Chem. 279(45): 47172-6.
  • Bass MD, et al. (2002) Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J. 368(Pt 1): 1-15.
  • Couchman JR, et al. (1999) Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J Cell Sci. 112 ( Pt 20): 3415-20.
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