Anti-Syndecan-4 Antibody

Cat: 50726-T16
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Anti-Syndecan-4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Syndecan-4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Syndecan-4
Immunogen
Recombinant Mouse Syndecan-4 / SDC4 protein (Catalog#50726-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Syndecan-4 / SDC4 (Catalog#50726-M08H; O35988; Met1-Val146). Syndecan-4 / SDC4 specific IgG was purified by Mouse Syndecan-4 / SDC4 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Syndecan-4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Syndecan-4 Antibody Alternative Names
Anti-AA959608 Antibody;Anti-AW108331 Antibody;Anti-ryudocan Antibody;Anti-Synd4 Antibody;Anti-syndecan-4 Antibody
Syndecan-4 Background Information

SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

Full Name
syndecan 4
References
  • Ikesue M, et al. (2011) Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arterioscler Thromb Vasc Biol. 31(5): 1066-74.
  • Saoncella S, et al. (2004) Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent manner. J Biol Chem. 279(45): 47172-6.
  • Bass MD, et al. (2002) Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J. 368(Pt 1): 1-15.
  • Couchman JR, et al. (1999) Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J Cell Sci. 112 ( Pt 20): 3415-20.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Syndecan-4 Antibody Rabbit Monoclonal WB,FCM,IP 50726-R112
    Anti-Syndecan-4 Antibody (PE) Rabbit Monoclonal FCM 50726-R112-P
    Anti-Syndecan-4 Antibody Rabbit Monoclonal IHC-P,ICC/IF,IF 50726-R047
    Anti-Syndecan-4 Antibody Rabbit Monoclonal ELISA 50726-R008
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