All Syndecan-1 reagents are produced in house and quality controlled, including 15 Syndecan-1 Antibody, 39 Syndecan-1 Gene, 1 Syndecan-1 IPKit, 4 Syndecan-1 Lysate, 4 Syndecan-1 Protein, 3 Syndecan-1 qPCR. All Syndecan-1 reagents are ready to use.
Recombinant Syndecan-1 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
Syndecan-1antibodies are validated with different applications, which are WB, IP, ELISA, FCM, IHC-P.
Syndecan-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Syndecan-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.