Syndecan-1 / SDC1 / CD138 Protein & Antibody

Cluster of Differentiation 138

Syndecan-1 / SDC1 / CD138 Products

Syndecan-1 / SDC1 / CD138 Protein, Recombinant

Molecule	Species	Description	Cat. No
Syndecan-1/SDC1/CD138	Human	Syndecan-1/SDC1/CD138 Protein, Recombinant	11429-H08H
Syndecan-1/SDC1/CD138	Mouse	Syndecan-1/SDC1/CD138 Protein, Recombinant	50641-M08H

Syndecan-1 / SDC1 / CD138 Antibody

Molecule	Application	Description	Cat. No
Mouse Syndecan-1 / SDC1 / CD138	WB, ELISA	Syndecan-1 / SDC1 / CD138 Antibody (Antigen Affinity Purified)	50641-RP02

Syndecan-1 / SDC1 / CD138 cDNA Clone

Molecule	Species	Description	Cat. No
Syndecan-1/SDC1/CD138	Human	Homo sapiens Syndecan-1/SDC1/CD138 cDNA Clone	HG11429-M
Syndecan-1/SDC1/CD138	Mouse	Mus musculus Syndecan-1/SDC1/CD138 cDNA Clone	MG50641-G
Syndecan-1/SDC1/CD138	Rat	SDC1 cDNA Clone / ORF Clone	RG80344-G

Syndecan-1 / SDC1 / CD138 Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Syndecan-1/SDC1/CD138

Immunology>>Cluster of Differentiation>>Syndecan-1/SDC1/CD138

Syndecan-1 / SDC1 / CD138 Alternative Names

Syndecan-1, SDC1, CD138, SDC, SYND1, syndecan [Homo sapiens]

Syndecan-1, Sdc1, CD138, AA408134, AA409076, Sstn, Synd, Synd1, syn-1, syndecan [Mus musculus]

Syndecan-1 / SDC1 / CD138 Background

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

Syndecan-1 / SDC1 / CD138 Related Studies

1. Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
2. Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
3. Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.