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Syndecan-1 / SDC1 / CD138 Antibody, Rabbit PAb, Antigen Affinity Purified

  • Syndecan-1 / SDC1 / CD138 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • Syndecan-1 / SDC1 / CD138 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Mouse SDC1 Antibody Product Information
Immunogen:Recombinant Mouse Syndecan-1 / SDC1 / CD138 protein (Catalog#50641-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Mouse Syndecan-1 / SDC1 / CD138 (rM Syndecan-1 / SDC1 / CD138; Catalog#50641-M08H; NP_035649.1; Met 1-Glu 252). Syndecan-1 / SDC1 / CD138 specific IgG was purified by Mouse Syndecan-1 / SDC1 / CD138 affinity chromatography.
Mouse SDC1 Antibody IHC Application Image
Syndecan-1 / SDC1 / CD138 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse SDC1 in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Syndecan-1 / SDC1 / CD138 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse SDC1 in mouse kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
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            Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
            Syndecan-1/CD138/SDC1 Background

            Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

            Mouse Syndecan-1/CD138/SDC1 References
          • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
          • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
          • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
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            Size / Price
            Catalog: 50641-RP02-200
            List Price: 
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            Datasheet & Documentation

            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"