|Recombinant Mouse Syndecan-1 / SDC1 / CD138 protein (Catalog#50641-M08H)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Mouse Syndecan-1 / SDC1 / CD138 (rM Syndecan-1 / SDC1 / CD138; Catalog#50641-M08H; NP_035649.1; Met 1-Glu 252). Syndecan-1 / SDC1 / CD138 specific IgG was purified by Mouse Syndecan-1 / SDC1 / CD138 affinity chromatography.|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse SDC1. The detection limit for Mouse SDC1 is approximately 0.039 ng/well.
IHC-P: 0.1-2 μg/mL
Application: WB IHC-P
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.