Syndecan-1 / SDC1 / CD138 Antibody (Antigen Affinity Purified)

Syndecan-1 / SDC1 / CD138 Antibody ( Antigen Affinity Purified ) Datasheet

Syndecan-1 / SDC1 / CD138 Antibody Product Information

• Immunogen: Recombinant Human Syndecan-1 / SDC1 / CD138 protein (Catalog#11429-H08H)
• Antibody Type: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: Produced in rabbits immunized with purified, recombinant Human Syndecan-1 / SDC1 / CD138 (rh Syndecan-1 / SDC1 / CD138; Catalog#11429-H08H; NP_002988.3; Met 1-Glu 251). Syndecan-1 / SDC1 / CD138 specific IgG was purified by Human Syndecan-1 / SDC1 / CD138 affinity chromatography.

Syndecan-1 / SDC1 / CD138 Antibody Usage Guide

• Specificity: Human Syndecan-1 / SDC1 / CD138
• Immunochemistry: IHC-P: 0.1-2 μg/mL

  

  Immunochemical staining of human SDC1 in human breast cancer with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to glandular epithelium.

  Immunochemical staining of human SDC1 in human colon cancer with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to glandular epithelium.

  

  Immunochemical staining of human SDC1 in human kidney with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections).

• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Syndecan-1 / SDC1 / CD138 Antibody Background

Syndecan-1, also known as SYND1, CD138 and SDC1, is a single-pass type I membrane protein which belongs to thesyndecan proteoglycan family. CD138 / Syndecan-1, is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. CD138 / Syndecan-1 is a cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. It is a cell-surface heparan sulfate proteoglycan expressed on most epithelial cells, and decreased CD138 expression is associated with increased invasive and metastatic potential in carcinomas. Within the hematopoietic system, CD138 is an excellent marker of plasmacytic differentiation. CD138 / Syndecan-1 is a cell surface proteoglycan that binds cells to the extracellular matrix and its expression is down-regulated in many cellular transformation models. CD138 / Syndecan-1 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C. The relevance of this marker in combination with other fibrosis markers should be explored. CD138 / Syndecan-1 might contribute to urothelial carcinoma cell survival and progression. It could be a new therapeutic target in human urinary bladder cancer.

References

1. O'Connell, FP. et al., Am J Clin Pathol2004, 121 (2):254-63.
2. Gokden,N.et al., 2006, Appl Immunohistochem Mol Morphol. 14 (2): 173-7.
3. Sun,WP. et al., 2007, Cell Mol Immunol. 4 (3): 209-14.
4. Zvibel, I. et al., 2009, Liver Int. 29 (2): 208-12.
5. Shimada,K. et al., 2010, Cancer Sci. 101 (1): 155-60.