SynCam / CADM1 Protein & Antibody (TSLC1, IGSF4)

Synaptic Cell Adhesion Molecule / Cell Adhesion Molecule 1 (Tumor Suppressor in Lung Cancer 1 / Immunoglobulin superfamily member 4)

SynCam / CADM1 Protein Products

SynCam / CADM1 Protein, Recombinant

Molecule	Species	Description	Cat. No
SynCam/CADM1/TSLC1	Human	SynCam/CADM1/TSLC1 Protein, Recombinant	11168-H08H

  11168-H08H:  Immobilized recombinant human CADM1 at 2 µg/ml (100 µl/well) can bind biotinylated human CRTAM with a linear range of 12.5–400 ng/ml. Measured by its binding ability in a functional ELISA.

SynCam / CADM1 Antibody

Molecule	Application	Description	Cat. No
Human SynCam/CADM1/TSLC1	WB, ELISA	Rabbit Polyclonal Antibody	11168-RP01

SynCam / CADM1 cDNA Clone

Molecule	Species	Description	Cat. No
SynCam/CADM1/TSLC1	Human	Homo sapiens SynCam/CADM1/TSLC1 cDNA Clone(NM_014333.3)	HG11168-M
SynCam/CADM1/TSLC1	Mouse	Mus musculus SynCam/CADM1/TSLC1 cDNA Clone	MG50538-M

SynCam / CADM1 Related Areas

Neuroscience>>Synaptic Protein>>SynCam/CADM1/TSLC1

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM)>>SynCam/CADM1/TSLC1

SynCam / CADM1 Alternative Names

SYNCAM, CADM1, TSLC1, IGSF4, IGSF4A, synCAM1, NECL2, Necl-2, RA175, BL2, DKFZp686F1789, MGC149785, MGC51880, ST17, sTSLC-1, sgIGSF [Homo sapiens]

SynCam, Cadm1, Tslc1, Igsf4, Igsf4a, Necl2, RA175, RA175A, RA175B, RA175C, RA175N, 2900073G06Rik, 3100001I08Rik, AI987920, Bl2, , ST17, SgIGSF [Mus musculus]

SynCam / CADM1 Background

Members of the immunoglobulin superfamily often play key roles in intercellular adhesion. IGSF4 is a novel immunoglobulin (Ig)-like intercellular adhesion molecule. Three Ig-like domains are included in the extracellular domain of IGSF4 and mediate homophilic or heterophilic interactions independently of Ca2+. The cytoplasmic domain of IGSF4 contains the binding motifs that connect to actin fibers. Since IGSF4 has been characterized by several independent research groups, this molecule is called by three names, TSLC1, SgIGSF and SynCAM. IGSF4 was first characterized as a tumor suppressor of non-small cell lung cancer and termed TSLC1. It is a single-pass type I membrane protein which belongs to the nectin family, which may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. In addition, CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. In neuroblastoma, loss of CADM1 expression has recently been found in disseminated tumours with adverse outcome, prompting us to investigate its role in neuroblastoma tumour progression. The downregulation of CADM1 tumour suppressor gene expression is a critical event in neuroblastoma pathogenesis resulting in tumour progression.

SynCam / CADM1 Related Studies

1. Watabe K, et al. (2003) IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. Histol Histopathol. 18(4): 1321-9.
2. Fujita E, et al. (2005) Distribution of RA175/TSLC1/SynCAM, a member of the immunoglobulin superfamily, in the developing nervous system. Brain Res Dev Brain Res. 154(2): 199-209.
3. Fujita E, et al. (2006) Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily. Mol Cell Biol. 26(2): 718-26.
4. Nowacki S, et al. (2008) Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma. Oncogene. 27(23): 3329-38.