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H1N1 Swine Flu (2009 Influenza Pandemic)

H1N1 Swine Flu (2009 Influenza Pandemic, 2009 Flu Pandemic)

The H1N1 swine flu or  2009 flu pandemic was an influenza pandemic, and the second of the two pandemics involving H1N1 influenza virus (the first of them was the 1918 flu pandemic), albeit in a new version. First described in April 2009, the virus appeared to be a new strain of H1N1 which resulted when a previous triple reassortment of bird, swine and human flu viruses further combined with a Eurasian pig flu virus, leading to the term "H1N1 swine flu" to be used for this pandemic. The 2009 flu pandemic (H1N1 swine flu) was one of the famous influenza pandemics in history. Unlike most strains of influenza, H1N1 does not disproportionately infect adults older than 60 years; this was an unusual and characteristic feature of the H1N1 pandemic. The 2009 pandemic influenza H1N1 (Novel Influenza A H1N1) Hemagglutinin (HA) proteins and antibodies were the main research tools for this influenza pandemic.

H1N1 Swine Flu History

The phylogenetic origin of the flu virus that caused the 2009 influenza pandemic can be traced before 1918. Around 1918, the ancestral virus, of avian origin, crossed the species boundaries and infected humans as human H1N1. The same phenomenon took place soon after in America, where the human virus was infecting pigs; it led to the emergence of the H1N1 swine strain, which later became the classic H1N1 swine flu.

New events of reassortment were not reported until 1968, when the avian strain H1N1 infected humans again; this time the virus met the strain H2N2, and the reassortment originated the strain H3N2. This strain has remained as a stable flu strain until now.

The mid-1970s were important for the evolution of flu strains. First, the re-emergence of the human H1N1 strain became a seasonal strain. Then, a small outbreak of swine H1N1 occurred in humans, and finally, the human H2N2 strain apparently became extinct. Around 1979, the avian H1N1 strain infected pigs and gave rise to Euroasiatic H1N1 swine flu and H1N1 Euroasiatic swine virus, which is still being transmitted in swine populations.

The critical moment for the 2009 outbreak was between 1990 and 1993. A triple reassortment event in a pig host of North American H1N1 swine virus, the human H3N2 virus and avian H1N1 virus generated the swine H1N2 strain. Finally, the last step in S-OIV history was in 2009, when the virus H1N2 co-infected a human host at the same time as the Euroasiatic H1N1 swine strain. This led to the emergence of a new human H1N1 strain, which caused the 2009 pandemic.

On June 11, 2009, the World Health Organization raised the worldwide pandemic alert level to Phase 6 for H1N1 swine flu, which is the highest alert level. This alert level means that the H1N1 swine flu had spread worldwide and there were cases of people with the virus in most countries. The pandemic level identifies the spread of the disease or virus and not necessarily the severity of the disease.

H1N1 Swine Flu Symptoms

According to the Centers for Disease Control and Prevention (CDC), in humans the symptoms of the 2009 "H1N1 swine flu" H1N1 virus are similar to those of influenza and of influenza-like illness in general. Symptoms include fever, cough, sore throat, body aches, headache, chills and fatigue. The 2009 outbreak has shown an increased percentage of patients reporting diarrhea and vomiting. The 2009 H1N1 virus is not zoonotic H1N1 swine flu, as it is not transmitted from pigs to humans, but from person to person. Because these symptoms are not specific to H1N1 swine flu, a differential diagnosis of probable H1N1 swine flu requires not only symptoms, but also a high likelihood of H1N1 swine flu due to the person's recent history. For example, during the 2009 H1N1 swine flu outbreak in the United States, the CDC advised physicians to "consider swine influenza infection in the differential diagnosis of patients with acute febrile respiratory illness who have either been in contact with persons with confirmed H1N1 swine flu, or who were in one of the five U.S. states that have reported H1N1 swine flu cases or in Mexico during the seven days preceding their illness onset." A diagnosis of confirmed H1N1 swine flu requires laboratory testing of a respiratory sample (a simple nose and throat swab).

H1N1 Swine Flu Deaths

The most common cause of H1N1 swine flu death is respiratory failure. Other causes of death are pneumonia (leading to sepsis), high fever (leading to neurological problems), dehydration (from excessive vomiting and diarrhea), electrolyte imbalance and kidney failure. Fatalities are more likely in young children and the elderly.

The total data of 2009 flu (H1N1 swine flu) pandemic deaths is 14,286 from ECDC, and 18,036 from WHO.

Swine Flu Virus (Protein, Antibody, ELISA kit & cDNA)

Pandemic H1N1/09 virus was found to be a novel strain of influenza for which extant vaccines against seasonal flu provided little protection. The virus is currently less lethal than previous pandemic strains and kills about 0.01–0.03% of those infected; the 1918 influenza was about one hundred times more lethal and had a case fatality rate of 2–3%.

In June 2010, scientists from Hong Kong reported discovery of a new H1N1 swine flu virus which is a hybrid of the pandemic H1N1 virus and viruses previously found in pigs. It is the first report of a reassortment of the pandemic virus, which in humans has been slow to evolve. Spread of the H1N1 virus is thought to occur in the same way that seasonal flu spreads. Flu viruses are spread mainly from person to person through coughing or sneezing by people with influenza.

Some representative 2009 flu virus stains are: H1N1, A/California/04/2009; A/California/07/2009; A/Beijing/22808/2009; A/England/195/2009; A/New York/18/2009; A/Ohio/07/2009; A/Texas/05/2009.

H1N1 Swine Flu Antibody against HA, NA & NP View antibody cross-reacting, click!

Product
(CLICK for detailed Info. and price)
Species Antibody
Type
Application Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody

2009 H1N1 Swine Flu

Rabbit PAb WB, ELISA 11055-RP02
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody (Antigen Affinity Prurified) 2009 H1N1 Swine Flu Rabbit PAb WB, ELISA 11055-RP03
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Rabbit PAb WB, ELISA 11055-RP07
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Mouse MAb WB, ELISA 11055-MM01
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Mouse MAb WB, ELISA 11055-MM04
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Mouse MAb WB, ELISA, FCM 11055-MM08
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Mouse MAb WB, ELISA 11055-MM09
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Mouse MAb ELISA 11055-MM11
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Rabbit MAb WB, ELISA 11055-RM05
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Rabbit MAb WB, ELISA 11055-RM06
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Rabbit MAb WB, ELISA 86001-RM01
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Rabbit MAb WB, ELISA 86001-RM02
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Antibody 2009 H1N1 Swine Flu Rabbit MAb WB, ELISA, B/N, FCM 11055-RM10
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neraminidase (NA) Antibody 2009 H1N1 Swine Flu Mouse MAb WB, ELISA 11058-MM07
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neraminidase (NA) Antibody 2009 H1N1 Swine Flu Mouse MAb WB, ELISA 11058-MM07
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neraminidase (NA) Antibody 2009 H1N1 Swine Flu Rabbit MAb WB, ELISA 11058-R001
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Nucleoprotein (NP) Antibody 2009 H1N1 Swine Flu Rabbit PAb WB, ELISA 11675-RP01
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Nucleoprotein (NP) Antibody 2009 H1N1 Swine Flu Rabbit PAb WB, ELISA 11675-RP02
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Nucleoprotein (NP) Antibody 2009 H1N1 Swine Flu Mouse MAb WB, ELISA 11675-MM03

H1N1 Swine Flu Pandemic Hemagglutinin (HA) Protein:

(1) 2009 H1N1 Swine Flu, A/California/07/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/California/07/2009
2009 H1N1 Swine Flu HA His Tag 11085-V08H

(2) 2009 H1N1 Swine Flu, A/California/04/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
2009 H1N1 Swine Flu HA His Tag 11055-V08H
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
2009 H1N1 Swine Flu HA His Tag 11055-V08H2
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
2009 H1N1 Swine Flu HA1 His Tag 11055-V08H4
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
2009 H1N1 Swine Flu HA His Tag 11055-V08B
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
2009 H1N1 Swine Flu HA2 Fc region of mouse IgG1 at the N-terminus 11055-V04H3

(3) 2009 H1N1 Swine Flu, A/England/195/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/England/195/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA His Tag 40005-V08H
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/England/195/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA1 His Tag 40005-V08H1

(4) 2009 H1N1 Swine Flu, A/New York/18/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/New York/18/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA His Tag 40009-V08H
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/New York/18/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA1 His Tag 40009-V08H1

(5) 2009 H1N1 Swine Flu, A/Ohio/07/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/Ohio/07/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA His Tag 40007-V08H

(6) 2009 H1N1 Swine Flu, A/Texas/05/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/Texas/05/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA His Tag 40006-V08H
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/Texas/05/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA1 His Tag 40006-V08H1

(7) 2009 H1N1 Swine Flu, A/Beijing/22808/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/Beijing/22808/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA His Tag 40035-V08H
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) Protein
H1N1, A/Beijing/22808/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu HA1 His Tag 40035-V08H1

H1N1 Swine Flu Pandemic Neuraminidase (NA) Protein

2009 H1N1 Swine Flu, A/California/04/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neuraminidase (NA) Protein
H1N1, A/California/04/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu NA Fc Tag 11058-V01H
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neuraminidase (NA) Protein
H1N1, A/California/04/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu NA His Tag 11058-V07H
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neuraminidase (NA) Protein
H1N1, A/California/04/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu NA His Tag 11058-V07B
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neuraminidase (NA) Protein
H1N1, A/California/04/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu NA  Native 11058-VNAHC
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neuraminidase (NA) Protein
H1N1, A/California/04/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu NA  Native 11058-VNAHC1
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Neuraminidase (NA) Protein
H1N1, A/California/04/2009 H1N1 Swine Flu
2009 H1N1 Swine Flu NA His Tag 11058-V07HC

H1N1 Swine Flu Pandemic Nucleoprotein (NP) Protein

2009 H1N1 Swine Flu , A/Puerto Rico/8/34/Mount Sinai

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Nucleoprotein (NP)
H1N1, A/Puerto Rico/8/34/Mount Sinai
2009 H1N1 Swine Flu NP His Tag 11675-V08B

H1N1 Swine Flu Pandemic Hemagglutinin (HA) ELISA Kit

2009 H1N1 Swine Flu, A/Califonia/04/2009

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Hemagglutinin (HA) ELISA Kit
A/California/04/2009
2009 H1N1 Swine Flu HA ELISA SEK001

H1N1 Swine Flu Pandemic Hemagglutinin (HA) cDNA clone: 2009 H1N1 Swine Flu

Product
(CLICK for detailed Info. and price)
Species Molecule Description Cat No
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Influenza Hemagglutinin (HA) cDNA clone
H1N1, A/California/04/2009
2009 H1N1 Swine Flu HA Codon Optimized VG11055-C
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Influenza Hemagglutinin (HA) cDNA clone
H1N1, A/California/07/2009
2009 H1N1 Swine Flu HA Codon Optimized VG11085-M
H1N1 Swine Flu Pandemic (2009 H1N1 Swine Flu) Influenza Hemagglutinin (HA) cDNA clone
H1N1, A/Puerto Rico/8/34/Mount Sinai
2009 H1N1 Swine Flu

HP

Codon Optimized VG11675-G

 

Worldwide Influenza Pandemics

Pandemic Influenza Outbreak-Finish Time Death toll Subtype involved
Russian Flu 1889–1890 1 million possibly H2N2
Spanish Flu 1918–1920 50 million H1N1
Asian Flu 1957–1958 1.5 to 2 million H2N2
Hong Kong Flu 1968–1969 1 million H3N2
H1N1 Swine Flu 2009–2010 over 18,209 novel H1N1

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