Sudan ebolavirus

Overview of Sudan ebolavirus

Sudan ebolavirus (SUDV or SEBOV) belongs to genus Ebolavirus which has other four species including Zaire Ebolavirus( ZEBOV / EBOV); Taï Forest ebolavirus (formerly Côte d'Ivoire ebolavirus, CIEBOV / TAFV,) and Bundibugyo ebolavirus (BEBOV / BDBV), Reston ebolavirus (REBOV / RESTV).The natural reservoirs of these negative- strand RNA viruses are thought to be various African fruit bats. Sudan ebolavirus (SUDV or SEBOV) first broke out in southern Sudan in June 1976. It also causes Ebola virus disease in human and non-human primates. The most recent outbreak occurred in June-Agust, 2012. 24 confirmed cases were reported in Uganda and 17 deaths. The fatality rate was as high as 71%. In October 2000, the third and largest outbreak of Sudan ebolavirus (SEBOV) infection occurred in the Gulu district of Uganda. During the course of the outbreak (August 2000–January 2001), 1400 cases of EBOV infection were identified. Similar to what had been reported for earlier Sudan ebolavirus (SEBOV) infection outbreaks, the case fatality rate was 53%, with a mean time to death of 8 days after onset of symptoms. Sudan ebolavirus (SEBOV) was associated with outbreaks in 1976 and 1979 in the southern Sudan towns of Nzara and Maridi; in 2000 in Gulu, Uganda; and in 2004 in Yambio, Sudan. The average fatality rates for Sudan ebolavirus (SUDV or SEBOV) were 54% in 1976, 68% in 1979, 53% in 2000 and 2001 and 41% in 2004.

Sudan ebolavirus Outbreak

EBOV Viral Molecule
Glycoprotein / EBOV-G
EBOV strain source
Subtype Zaire, strain Mayinga 1976
Subtype Sudan, strain Gulu
Subtype Bundibugyo, strain Bundibugyo 2007
EBOV Infection Receptor
TGF-beta 1 / TGFB1
TGF-beta 2 / TGFB2
TGF-beta 3 / TGFB3
EBOV Infection Associated
ICAM-3 / CD50
TNFA / TNF-alpha
EBOV Information
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Zaire ebolavirus
Sudan ebolavirus
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