Src Family Kinase (SFK)

Sino Biological provides a comprehensive set of tools for Src family kinase (SFK) related studies, including proteins, antibodies (rabbit mAbs, mouse mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.

Src Family Kinase (SFK) Products

• BLK
• Lyn
• YES1 / c-Yes
• Lck
• C-Src

Src Family Kinase (SFK) Background

Src family kinase (SFK) is a family of non-receptor tyrosine kinases including nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.

In immune cells, Src-family kinases (SFKs) have been implicated as critical regulators of a large number of intracellular signaling pathways. Src-family kinases (SFKs) occupy a proximal position in numerous signaling transduction cascades including those emanating from the T and B cell antigen receptors, Fc receptors, growth factor receptors, cytokine receptors, and integrins. In addition to these positive regulatory roles, Src-family kinases (SFKs) can also function as negative regulators of cellular signaling by phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, resulting in recruitment and activation of inhibitory molecules such as the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1).

Src Family Kinase (SFK) Related Studies

1. Lowell CA. (2004) Src-family kinases: rheostats of immune cell signaling. Mol Immunol. 41(6-7):631-43.
2. Geahlen RL, et al. (2004) Molecular interdiction of Src-family kinase signaling in hematopoietic cells. Oncogene. 23(48):8024-32.
3. Silva CM. (2004) Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene. 23(48):8017-23.
4. Hermiston ML, et al. (2009) CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev. 228(1):288-311.