Serum amyloid P component Protein (SAP, APCS Protein)

Serum Amyloid P Component Products

Serum Amyloid P Component Protein, Recombinant

Molecule	Species	Description	Cat. No
Serum Amyloid P Component/SAP	Mouse	Serum amyloid P component/SAP Protein, Recombinant	50113-M08H
Serum Amyloid P Component/SAP	Rat	Serum amyloid P component / APCS Protein, Recombinant	80061-R08H

  50113-M08H:

1. Immobilized mouse APCS at 10 µg/ml (100 µl/well) can bind biotinylated human Fibronectin Fragment 2 with a linear ranger of 0.625-5 µg/ml. Measured by its binding ability in a functional ELISA.

2. Measured by its ability to bind mouse CD64-AVI in a functional Elisa.

Serum Amyloid P Component Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse Serum Amyloid P Component/SAP	ELISA	Serum amyloid P component / APCS Antibody (Antigen Affinity Purified)	50113-RP02

Serum Amyloid P Component cDNA Clone Products

Molecule	Species	Description	Cat. No
Serum Amyloid P Component/SAP	Mouse	Mus musculus Serum amyloid P component/SAP cDNA Clone	MG50113-M
Serum Amyloid P Component/SAP	Rat	Rat Serum amyloid P component/SAP cDNA Clone / ORF Clone	RG80061-M

Serum Amyloid P Component Related Areas

Immunology>>Innate Immunity>>Acute Phase Proteins>>Serum Amyloid P Component/SAP

Serum Amyloid P Component Alternative Names

APCS, SAP, PTX2, MGC88159 [Homo sapiens]

Apcs, Sap [Mus musculus]

Serum Amyloid P Component Background

Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.

Serum Amyloid P Component Related Studies

1. Wang Y, et al. (2011) Human serum amyloid P functions as a negative regulator of the innate and adaptive immune responses to DNA vaccines. J Immunol. 186(5): 2860-70.
2. Hawkins PN. (2002) Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis. Curr Opin Nephrol Hypertens. 11(6): 649-55.
3. Noursadeghi M, et al. (2000) Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Proc Natl Acad Sci U S A. 97: 14584–9.
4. de Haas CJ. (1999) New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein. FEMS Immunol Med Microbiol. 26(3-4): 197-202.