Anti-Serum Amyloid P Antibody

Cat: 50113-RP02
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All Serum Amyloid P Reagents
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All Serum Amyloid P Reagents
Anti-Serum Amyloid P Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Serum Amyloid P Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse Serum Amyloid P
Recombinant Mouse Serum amyloid P component / APCS protein (Catalog#50113-M08H)
Produced in rabbits immunized with purified, recombinant Mouse Serum amyloid P component / APCS (rM Serum amyloid P component / APCS; Catalog#50113-M08H; NP_035448.2; Met 1-Glu 224). Serum amyloid P component / APCS specific IgG was purified by Mouse Serum amyloid P component / APCS affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Serum Amyloid P Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Serum Amyloid P Antibody Alternative Names
Anti-Sap Antibody
Serum Amyloid P Background Information

Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.

Full Name
amyloid P component, serum
  • Wang Y, et al. (2011) Human serum amyloid P functions as a negative regulator of the innate and adaptive immune responses to DNA vaccines. J Immunol. 186(5): 2860-70.
  • Hawkins PN. (2002) Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis. Curr Opin Nephrol Hypertens. 11(6): 649-55.
  • Noursadeghi M, et al. (2000) Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Proc Natl Acad Sci U S A. 97: 14584-9.
  • de Haas CJ. (1999) New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein. FEMS Immunol Med Microbiol. 26(3-4): 197-202.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Serum Amyloid P Antibody Rabbit Polyclonal ELISA 50113-RP01
    Anti-Serum Amyloid P Antibody Rabbit Polyclonal ELISA 13610-T16
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