|Recombinant Mouse Serum amyloid P component / APCS protein (Catalog#50113-M08H)|
|0.2 μm filtered solution in PBS with 5% trehalose|
|Produced in rabbits immunized with purified, recombinant Mouse Serum amyloid P component / APCS (rM Serum amyloid P component / APCS; Catalog#50113-M08H; NP_035448.2; Met 1-Glu 224). Serum amyloid P component / APCS specific IgG was purified by Mouse Serum amyloid P component / APCS affinity chromatography.|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse APCS. The detection limit for Mouse APCS is approximately 0.00975 ng/well.
Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.