SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, and PI-6, is a cytoplasm protein which belongs to the Ov-serpin subfamily of serpin family. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 is expressed in keratinocytes (at protein level) and inner ear hair cells. It is also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. It expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. SerpinB6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Defects in SerpinB6 are the cause of deafness autosomal recessive type 91 which is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. SerpinB6B is a member of SerpinB6 subfamily.
Serpinb6b ELISA Pair sets
Serpinb6b cDNA Clones
RP23-391I11.3, NK13, Spi12, ovalbumin [Mus musculus]
Wikipedia summary for Serpinb6b:
Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.
Serine (Or cysteine) peptidase inhibitor, clade B, member 6b
Belongs to the serpin family.
General information above from UniProt