Serpinb3c

SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.

Serpinb3c Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SERPINB3 / SCCA-1

Serpinb3c Alternative Names

SCCA-PD, SCCA1, T4-A, protein T4-A, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, serpin B3, squamous cell carcinoma antigen 1 [Homo sapiens]

Summaries for Serpinb3c

Wikipedia summary for Serpinb3c:

Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene.

Mouse Serpinb3c Protein General Information

 

• Protein names: Serpinb3c
• Sequence length: 386 AA.
• Sequence similarities: Belongs to the serpin family.

General information above from UniProt

Function for Serpinb3c Protein

Genatlas:

• Serpinb3c is serine proteinase inhibitor of cathepsin S, K and L
• Serpinb3c may act as a protease inhibitor to modulate the host immune response against tumor cells
• Serpinb3c may be involved in the malignant behavior of squamous cell carcinoma cells
• with SERPINB3, Serpinb3c stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines
• Serpinb3c plays an important role of SERPINB3 in the modulation of programmed cell death by different mechanisms, both in inflammatory processes and in cancer
• SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells
• Serpinb3c's anti-protease activity might be implicated in TGF-beta1 induction
• with SERPINB4, are tumor-associated proteins that can inhibit papain-like cysteine proteases, including cathepsins L, K, and S

Homology for human Serpinb3c

• homolog to C.elegans Srp2