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> SERPINB3 / SCCA-1 Protein & Antibody SERPINB3 / SCCA-1 Protein & Antibody
serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB3 / SCCA-1 Products
SERPINB3 / SCCA-1 Protein & Antibody
Sino Biological offers a comprehensive set of research tools (proteins, antibodies) for SERPINB3 / SCCA-1 related research. We offer SERPINB3 / SCCA-1 proteins and receptors from human and mouse. Our antibody products include rabbit polyclonal antibodies for application such as ELISA, Western Blotting, etc. All of our antibodies were generated with recombinant protein as immunogen, which ensures better binding affinity and specificity to the native protein.
SERPINB3 / SCCA-1 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| SERPINB3 / SCCA-1 | Human | SERPINB3 / SCCA-1 Protein, Recombinant (His Tag) | 13218-H07B |
| SERPINB3c | Mouse | SERPINB3c Protein, Recombinant (His Tag) | 50625-M08B |
SERPINB3 / SCCA-1 Antibody
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
SERPINB3c |
Mouse | Serpinb3c Antibody, Rabbit PAb | 50625-RP01 |
SERPINB3c |
Mouse | Serpinb3c Antibody, Rabbit PAb (Antigen Affinity Purified) | 50625-RP02 |
SERPINB3 / SCCA-1 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| SERPINB3 / SCCA-1 | Human | Human SERPINB3 / SCCA-1 cDNA Clone / ORF Clone | HG13218-G |
| SERPINB3c | Mouse | Mouse Serpinb3c cDNA Clone / ORF Clone | MG50625-M |
SERPINB3 / SCCA-1 Related Areas
Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SERPINB3 / SCCA-1
SERPINB3 / SCCA-1 Alternative Names
SCCA-PD, SCCA1, T4-A, protein T4-A, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, serpin B3, squamous cell carcinoma antigen 1 [Homo sapiens]
SERPINB3 / SCCA-1 Related Products
Protein Products
Antibody Products
cDNA Clone Products
SERPINB3 / SCCA-1 Background
SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.
SERPINB3 / SCCA-1 Related Studies
- Schneider SS, et al. (1995) A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci. 92(8):3147-51.
- Suminami Y, et al.. (1992) Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. Biochem Biophys Res Commun. 181(1):51-8.
- Mino-Miyagawa N, et al. (1990) Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus. Cancer. 66(7):1505-12.
