Anti-Serpinb3c Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Mouse
Recombinant Mouse Serpinb3c protein (Catalog#50625-M08B)
Produced in rabbits immunized with purified, recombinant Mouse Serpinb3c (rM Serpinb3c; Catalog#50625-M08B; NP_958751.2; Met 1-Pro 386). Total IgG was purified by Protein A affinity chromatography
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Serpinb3c Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Serpinb3c Antibody Alternative Names
Anti-1110001H02Rik Antibody;Anti-1110013A16Rik Antibody;Anti-Scca2 Antibody;Anti-Serpinb3c Antibody;Anti-Serpinb4 Antibody
Serpinb3c Background Information
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified.
Mouse SerpinB3, also known as Squamous cell carcinoma antigen 1, SCCA-1, SERPINB3, SCCA and SCCA1, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB3 may act as a protease inhibitor to modulate the host immune response against tumor cells. Mouse SerpinB3a and SerpinB3b, but not Serpinb3c, are functional, inhibiting both serine and cysteine proteinases with different inhibitory profiles due to the difference of two amino acids in their reactive site loops. SerpinB3a is ubiquitously expressed in most tissues, whereas expression of SerpinB3b is limited to keratinocytes. SerpinB3a and SerpinB3b may play different roles by inhibiting intrinsic or extrinsic proteinases with different expression distributions and different inhibitory profiles.
serine (or cysteine) peptidase inhibitor, clade B, member 3C
Sakata,Y. et al., 2004, Biochem Biophys Res Commun.324 (4):1340-5. Horvath, AJ. et al., 2004, J. Mol. Evol. 59: 488-97. Steenbakkers PJ. et al., 2008, Mycol. Res. 112 (Pt 8): 999-1006. Przygodzka, P. et al., 2010, BMC Cell Biol. 11: 30.