SerpinI2

 

SerpinI2 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinI2

SerpinI2 Alternative Names

SerpinI2, MEPI, PANCPIN, PI14, TSA2004 [Homo sapiens]

Serpini2, 1810006A24Rik, Spi14 [Mus musculus]

Summaries for SerpinI2

Entrez Gene summary for SerpinI2:

The protein encoded by SERPINI2 gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for SERPINI2 gene. [provided by RefSeq, Jul 2008]

Wikipedia summary for SerpinI2:

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.
The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

Human SerpinI2 Protein General Information

 

• Protein names: SerpinI2
• Sequence length: 405 AA.
• Domain: Signal
• Sequence similarities: Belongs to the serpin family.
• Subcellular location: Secreted
• Tissue specificity: Expressed in pancreas and adipose tissues.
• Sequence caution: The sequence AAH27859.2 differs from that shown. Reason: Erroneous initiation.

General information above from UniProt

Function for SerpinI2 Protein

Genatlas:

• SerpinI2 may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis

Homology for human SerpinI2

• homolog to rattus Serpini2
• homolog to serpin ZG-46p