Anti-Neuroserpin Antibody

Cat: 11107-RP02
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All Neuroserpin Reagents
Anti-Neuroserpin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Neuroserpin Antibody
Validated applications
WB,ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Neuroserpin
Immunogen
Recombinant Human SerpinI1 protein (Catalog#11107-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SerpinI1 (rh SerpinI1; Catalog#11107-H08H; NP_005016.1; Met 1-Leu 410). SerpinI1 specific IgG was purified by Human SerpinI1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Neuroserpin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Neuroserpin Antibody (Rabbit Polyclonal antibody) Images
Human Neuroserpin/SerpinI1 Immunohistochemistry(IHC) 3612
Immunochemical staining of human SerpinI1 in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human Neuroserpin/SerpinI1 Western blot (WB) 13345

Anti-SERPINI1 rabbit polyclonal antibody at 1:500 dilution

Lane A: Mouse brain Tissue Lysate

Lane B: Rat brain Tissue Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:46 kDa

Observed band size:52 kDa

(We are unsure as to the identity of these extra bands.)

Anti-Neuroserpin Antibody Alternative Names
Anti-neuroserpin Antibody;Anti-PI12 Antibody
Neuroserpin Background Information

Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein which belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons. Neuroserpin is predominantly expressed in the brain, and is expressed in the late stages of neurogenesis during the process of synapse formation. Overexpression of neuroserpin in an anterior pituitary corticotroph cell line results in the extension of neurite-like processes, suggesting that neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration. Neuroserpin may be involved in the formation or reorganization of synaptic connections, as well as synaptic plasticity in the adult nervous system. Neuroserpin may also protect neurons from cell damage by tissue-type plasminogen activator. Defects of neuroserpin are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B).

Full Name
serpin peptidase inhibitor, clade I (neuroserpin), member 1
References
  • Schrimpf SP. et al., 1997, Genomics. 40 (1): 55-62.
  • Hill RM. et al., 2002, Ann N Y Acad Sci. 971: 406-15.
  • Yepes M. et al., 2004, Thromb. Haemost. 91 (3): 457-64.
  • Galliciotti G. et al., 2006, Front Biosci. 11: 33-45.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Neuroserpin Antibody Rabbit Monoclonal IHC-P 50926-R002
    Anti-Neuroserpin Antibody Rabbit Monoclonal ELISA 50926-R009
    Anti-Neuroserpin Antibody Rabbit Polyclonal ELISA 50926-RP01
    Anti-Neuroserpin Antibody Rabbit Polyclonal WB,ELISA 50926-RP02
    Anti-Neuroserpin Antibody Rabbit Monoclonal ELISA 11107-R001
    Anti-Neuroserpin Antibody Mouse Monoclonal ELISA,IHC-P 11107-MM08
    Anti-Neuroserpin Antibody Rabbit Polyclonal ELISA 11107-RP01
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