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> SerpinF2 Protein & Antibody SerpinF2 Protein & Antibody
Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SerpinF2 Products
SerpinF2 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| SerpinF2 | Human | SerpinF2 Protein, Recombinant |
10297-H08H |
| SerpinF2 | Mouse | SerpinF2 Protein, Recombinant |
50167-M08H |
SerpinF2 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human SerpinF2 |
WB, ELISA | SerpinF2 Antibody, Mouse MAb | 10297-MM05 |
| Human SerpinF2 |
WB, ELISA | SerpinF2 Antibody, Rabbit PAb | 10297-RP01 |
| Human SerpinF2 |
WB, ELISA | SerpinF2 Antibody, Rabbit PAb (Antigen Affinity Purified) | 10297-RP02 |
| Mouse SerpinF2 |
WB, ELISA | Rabbit Monoclonal Antibody | 50167-R128 |
| Mouse SerpinF2 |
WB, ELISA | Rabbit Polyclonal Antibody | 50167-RP01 |
| Mouse SerpinF2 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 50167-RP02 |
SerpinF2 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| SerpinF2 | Human | Homo sapiens SerpinF2 cDNA Clone(NM_000934.3) | HG10297-M |
| SerpinF2 | Mouse | Mus musculus SerpinF2 cDNA Clone | MG50167-M |
SerpinF2 Related Areas
Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinF2
Immunology>>Innate Immunity>>Coagulation>>SerpinF2
Cardiovascular>>Coagulation>>SerpinF2
SerpinF2 Alternative Names
SERPINF2, A2AP, AAP, ALPHA-2-PI, API, PLI [Homo sapiens]
Serpinf2, RP23-384C18.2, AI747498, Pli, Serpimf2 [Mus musculus]
SerpinF2 Related Products
Protein Products
Antibody Products
Elisa Pair Set
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human PEDF/SerpinF1 |
ELISA | PEDF/SerpinF1 ELISA Pair Set | SEK50167 |
cDNA Clone Products
SerpinF2 Background
SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed in muscle, intestine, central nervous system, and placenta also express this protein at a moderate level. It is indicated that Serpin F2 is a key regulator of plasmin-mediated proteolysis in these tissues. Alpha-2 AP is an unusual serpin in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. SerpinF2 is one of the inhibitors of fibrinolysis, which acts as the primary inhibitor of plasmin(ogen). It is a specific plasmin inhibitor, and is important in modulating the effectiveness and persistence of fibrin with respect to its susceptibility to digestion and removal by plasmin. Alpha-2 AP plays the dominant role in inhibiting both plasma clot lysis and thrombus lysis, and accordingly, the congenital deficiency of Alpha-2 antiplasmin causes a rare bleeding disorder because of increased fibrinolysis. Thus, it may be a useful target for developing more effective treatment of thrombotic diseases.
SerpinF2 Related Studies
- Lee KN, et al. (2004) Alpha2-antiplasmin: potential therapeutic roles in fibrin survival and removal. Curr Med Chem Cardiovasc Hematol Agents. 2(4): 303-10.
- Matsuno H. (2006) Alpha2-antiplasmin on cardiovascular diseases. Curr Pharm Des. 12(7): 841-7.
- Burnouf T, et al. (2007) Impact of Triton X-100 on alpha 2-antiplasmin (SERPINF2) activity in solvent/detergent-treated plasma. Biologicals. 35(4): 349-53.
- Carpenter SL, et al. (2008) Alpha2-antiplasmin and its deficiency: fibrinolysis out of balance. Haemophilia. 14(6): 1250-4.
