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> SerpinD1 Protein & Antibody SerpinD1 Protein & Antibody
Serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SerpinD1 Products
SerpinD1 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| SerpinD1 | Human | SerpinD1 Protein, Recombinant | 10295-H08H |
| SerpinD1 | Mouse | SerpinD1 Protein, Recombinant |
50121-M08H |
SerpinD1 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human SerpinD1 |
WB, ELISA | SerpinD1 Antibody, Rabbit PAb | 10295-RP01 |
| Human SerpinD1 |
WB, ELISA | SerpinD1 Antibody, Rabbit PAb (Antigen Affinity Purified) | 10295-RP02 |
| Mouse SerpinD1 |
WB, ELISA | SerpinD1 Antibody, Rabbit MAb | 50121-R025 |
| Mouse SerpinD1 |
WB, ELISA | Rabbit Polyclonal Antibody | 50121-RP01 |
| Mouse SerpinD1 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 50121-RP02 |
SerpinD1 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| SerpinD1 | Human | Homo sapiens SerpinD1 cDNA Clone(NM_000185.3) | HG10295-M |
| SerpinD1 | Mouse | Mus musculus SerpinD1 cDNA Clone | MG50121-M |
SerpinD1 Related Areas
Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinD1
Immunology>>Innate Immunity>>Coagulation>>SerpinD1
Cardiovascular>>Coagulation>>SerpinD1
SerpinD1 Alternative Names
SERPIND1, HCII, HC2, HCF2, HLS2, LS2, D22S673, [Homo sapiens]
SerpinD1, HCII, Hcf2, AA985900, AI303446, MGC107662 [Mus musculus]
SerpinD1 Related Products
Protein Products
Antibody Products
cDNA Clone Products
SerpinD1 Background
SerpinD1, also known as heparin cofactor II (HCâ…¡), is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
SerpinD1 Related Studies
- Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.
- Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.
