Quick Order

SerpinD1 / HCII Antibody, Rabbit PAb, Antigen Affinity Purified

  • SerpinD1 / HCII Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
DatasheetReviewsRelated ProductsProtocols
Mouse SerpinD1 Antibody Product Information
Immunogen:Recombinant Mouse SerpinD1 protein (Catalog#50121-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse SerpinD1 (rM SerpinD1; Catalog#50121-M08H; NP_032249.3; Met 1-Ser 478). SerpinD1 specific IgG was purified by mouse SerpinD1 affinity chromatography.
Mouse SerpinD1 Antibody IHC Application Image
SerpinD1 / HCII Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse SERPIND1 in mouse liver with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
Other SerpinD1 Antibody Products
Reactivity: Human  
Application: IHC-P  
  • Slide 1
  • Slide 1
10295-R008-50
10295-R008-100
50 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  WB  
  • Slide 1
10295-RP01-400
10295-RP01-200
10295-RP01-100
400 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  WB  IP  
  • Slide 1
  • Slide 1
10295-RP02-50
10295-RP02-200
10295-RP02-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10295-MM02-50
    10295-MM02-200
    10295-MM02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: IHC-P  
    • Slide 1
    • Slide 1
    10295-MM07-50
    10295-MM07-200
    10295-MM07-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  
      50121-RP01-400
      50121-RP01-200
      50121-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  WB  IP  
      • Slide 1
      • Slide 1
      50121-R025-50
      50121-R025-100
      50 µg 
      100 µg 
      Add to Cart
      SerpinD1 Background

      SerpinD1, also known as heparin cofactor II (HCâ…¡), is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

      Mouse SerpinD1 References
    • Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.
    • Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.
    • Product nameProduct name
      Size / Price
      Catalog: 50121-RP02-50
      List Price: 
      Price:      (You Save: )

      Datasheet & Documentation

      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"