SerpinB9

SerpinB9 is granzyme B inhibitor.

SerpinB9 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinB9

SerpinB9 Alternative Names

SerpinB9, CAP-3, CAP3, PI9 [Homo sapiens]

Serpinb9, RP23-391I11.1, BB283241, CAP-3, CAP3, PI-9, PI9, Spi6, ovalbumin [Mus musculus]

Summaries for SerpinB9

Entrez Gene summary for SerpinB9:

SerpinB9 gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of SerpinB9 gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

OMIM - description for SerpinB9:

PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).

Wikipedia summary for SerpinB9:

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene.
PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).

Human SerpinB9 Protein General Information

 

• Protein names: SerpinB9
• Sequence length: 376 AA.
• Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.
• Subcellular location: Cytoplasm.

General information above from UniProt

Function for SerpinB9 Protein

UniProtKB:

SerpinB9 is granzyme B inhibitor.

Genatlas:

• SerpinB9 can regulate pro-apoptotic apical caspases
• SerpinB9 is potent inhibitor of GZMB, and protects testicular Sertoli cells and placental syncytial trophoblasts from GZMB-producing auto- or allo-reactive cytotoxic lymphocytes

Homology for human SerpinB9

• homolog to highly,to the genes of the serpin cluster on chromosome 18 (SPI@2)