SerpinB8

 

SerpinB8 Related Areas

Cardiovascular>>Platelet>>SerpinB8

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinB8

SerpinB8 Alternative Names

SerpinB8, CAP2, PI8 [Homo sapiens]

SerpinB8, CAP-2, CAP2, NK10, Spi8, ovalbumin [Mus musculus]

Summaries for SerpinB8

Entrez Gene summary for SerpinB8:

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 ).[supplied by OMIM, Jan 2010]

OMIM - description for SerpinB8:

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 , is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997).

Wikipedia summary for SerpinB8:

Serpin B8 is a protein that in humans is encoded by the SERPINB8 gene.

Human SerpinB8 Protein General Information

 

• Protein names: SerpinB8
• Sequence length: 374 AA.
• Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.
• Subcellular location: Cytoplasm.

General information above from UniProt

Function for SerpinB8 Protein

Genatlas:

• SerpinB8 plays a role in platelet-regulated pathophysiological responses