Anti-SerpinB6 Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Human
Recombinant Human SerpinB6 protein (Catalog#12837-H07B)
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinB6 (rh SerpinB6; Catalog#12837-H07B; AAB30320.1; Asp 2-Pro 376).
Monoclonal Rabbit IgG Clone #309
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SerpinB6 Antibody (Rabbit Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-SerpinB6 Antibody Alternative Names
Anti-CAP Antibody;Anti-DFNB91 Antibody;Anti-DKFZp686I04222 Antibody;Anti-MGC111370 Antibody;Anti-MSTP057 Antibody;Anti-PI-6 Antibody;Anti-PI6 Antibody;Anti-PTI Antibody;Anti-RP1-90J20.6 Antibody;Anti-SPI3 Antibody
SerpinB6 Background Information
SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is expressed in keratinocytes (at protein level). It is also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. SerpinB6 / PI-6 is expressed in the inner ear hair cells. It expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. SerpinB6 / PI-6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Defects in SerpinB6 are the cause of deafness autosomal recessive type 91 which is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
serpin peptidase inhibitor, clade B (ovalbumin), member 6
Morgenstern KA. et al.,1994, Biochemistry. 33: 3432-41. Strik MC. et al., 2004, Blood. 103: 2710-7. Scott FL. et al., 2007, J Biochem. 142: 435-42. Burkard TR. et al., 2011, BMC Syst Biol. 5:17.