SerpinB4 Protein & Antibody

Serpin peptidase inhibitor, clade B (ovalbumin), member 4

SerpinB4 Products

SerpinB4 Protein, Recombinant

Molecule	Species	Description	Cat. No
SerpinB4	Human	SerpinB4 Protein, Recombinant	12990-H07B

SerpinB4 Antibody

Molecule	Application	Description	Cat. No
Human SerpinB4	IHC-P	SerpinB4 Antibody	12990-MM05

SerpinB4 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinB4

SerpinB4 Alternative Names

SerpinB4, LEUPIN, PI11, SCCA-2, SCCA1, SCCA2 [Homo sapiens]

SerpinB4 Background

SerpinB4, also known as Squamous cell carcinoma antigen 2 (SCCA2), belongs to the high-molecular weight serine proteinase inhibitor (serpin) family. Squamous cell carcinoma antigen (SCCA) is expressed in normal squamous cell epithelia and in squamous cell carcinomas (SCC). Two nearly identical genes encode the inhibitory serpins SCCA1 (SERPINB3) and SCCA2 (SERPINB4). SerpinB4 formed a typical serpin-protease SDS-stable complex with both recombinant and native human granzyme GrM. SCCA2 expression is significantly related to E-cadherin expression and that the heterogeneous pattern of SCCA and E-cadherin in primary lesions is strongly associated with the high incidence of lymph node metastasis in cervical squamous cell carcinoma. Serpins (serine protease inhibitors) are known as a diverse family of protease inhibitors; however, various other biological activities including tumor suppression, have been recently reported for these molecules. SCCA2 may be involved in cancer behavior such as metastasis, and as such can be a useful marker in predicting lymph node metastasis.

SerpinB4 Related Studies

1. de Koning PJ, et al. (2011) Intracellular Serine Protease Inhibitor SERPINB4 Inhibits Granzyme M-Induced Cell Death. PLoS One. 6(8): e22645.
2. Chechlinska M, et al. (2010) Squamous cell carcinoma antigen 1 and 2 expression in cultured normal peripheral blood mononuclear cells and in vulvar squamous cell carcinoma. Tumour Biol. 31(6): 559-67.
3. Shiiba M, et al. (2010) Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas. Oncol Rep. 24(1): 241-9. en, Der p 1. J Biol Chem. 279(7): 5081-7.
4. Murakami A, et al. (2008) Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Oncol Rep. 19(1): 99-104.
5. Silverman GA, et al. (1998) SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3. Tumour Biol. 19(6): 480-7.