SerpinB2 (PAI-2)

SerpinB2 inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

SerpinB2 (PAI-2) Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinB2/PAI-2

Immunology>>Innate Immunity>>Coagulation>>SerpinB2/PAI-2

SerpinB2 (PAI-2) Alternative Names

SerpinB2, HsT1201, PAI, PAI-2, PAI2, PLANH2 [Homo sapiens]

Serpinb2, PAI-2, Planh2, ovalbumin [Mus musculus]

Summaries for SerpinB2 (PAI-2)

Wikipedia summary for SerpinB2 (PAI-2):

Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. SerpinB2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.
It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Human SerpinB2 (PAI-2) Protein General Information

 

• Protein names: SerpinB2
  Plasminogen activator inhibitor 2
  Short name=PAI-2
• Sequence length: 415 AA.
• Domain: Signal
• Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.
• Post-translational modification: The signal sequence is not cleaved.
• Subunit structure: Interacts with PSMB1.
• Subcellular location: Cytoplasm. Secreted › extracellular space.

General information above from UniProt

Function for SerpinB2 (PAI-2) Protein

UniProtKB:

SerpinB2 inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Genatlas:

• SerpinB2 is serine proteinase inhibitor
• SerpinB2 is plasminogen activator inhibitor type 2
• SerpinB2 inhibits extracellular matrix degradation by PLAU (urokinase inhibitor)