SerpinB10

SerpinB10 is protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. SerpinB10 may regulate protease activities in the cytoplasm and in the nucleus.

SerpinB10 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinB10

SerpinB10 Alternative Names

SerpinB10, PI10, bomapin, PI-10 [Homo sapiens]

Serpinb10, Serpinb10-ps, 9830131G07, BB233602 [Mus musculus]

Summaries for SerpinB10

Entrez Gene summary for SerpinB10:

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 , is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

OMIM - description for SerpinB10:

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 , is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997).

Human SerpinB10 Protein General Information

 

• Protein names: SerpinB10
• Sequence length: 397 AA.
• Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.
• Subcellular location: Nucleus. Cytoplasm
• Tissue specificity: Expressed specifically in the bone marrow.

General information above from UniProt

Function for SerpinB10 Protein

UniProtKB:

SerpinB10 is protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. SerpinB10 may regulate protease activities in the cytoplasm and in the nucleus.

Genatlas:

• SerpinB10 may play a role in the regulation of protease activities during hematopoiesis
• SerpinB10 inhibits tumor necrosis factor alpha -induced cell death