SerpinB1 (ELANH2)

SerpinB1 regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3.

SerpinB1 (ELANH2) Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinB1/ELANH2

SerpinB1 (ELANH2) Alternative Names

SerpinB1, ELANH2, EI, LEI, M/NEI, MNEI, PI2 [Homo sapiens]

Serpinb1a, ELANH2, RP23-427P14.4, 1190005M04Rik, AI325983, EI, EIA, LEI, M/NEI, MGC129309, MNEI, PI2 [Mus musculus]

Summaries for SerpinB1 (ELANH2)

Wikipedia summary for SerpinB1 (ELANH2):

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene.

Human SerpinB1 (ELANH2) Protein General Information

 

• Protein names: SerpinB1
• Sequence length: 379 AA.
• Domain: Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or chymase, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophyl elastase, proteinase-3, pancreatic elastase or PSA.
• Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.
• Sequence caution: The sequence BAD97090.1 differs from that shown. Reason: Erroneous initiation.
• Subcellular location: Cytoplasm

General information above from UniProt

Function for SerpinB1 (ELANH2) Protein

UniProtKB:

SerpinB1 regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3.

Genatlas:

• SerpinB1 regulates acitivity of the neutrophil proteases, elastase, cathepsin G and proteinase 3