Anti-TBG Antibody

Cat: 10993-R010
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Anti-TBG Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-TBG Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TBG
Immunogen
Recombinant Human SerpinA7 protein (Catalog#10993-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA7 (rh SerpinA7; Catalog#10993-H08H; NP_000345.2; Met 1-Ala 415).
Source
Monoclonal Rabbit IgG Clone #010
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TBG Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TBG Antibody Alternative Names
Anti-TBG Antibody
TBG Background Information

Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to the serpin family. TBG is synthesized primarily in the liver as a 54 kDa protein.TBG is genomically a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.

Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
References
  • Flink I.L., et al.,(1986), Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Proc. Natl. Acad. Sci. U.S.A. 83:7708-7712.
  • Akbari M.T., et al., (1993), The structure of the human thyroxine binding globulin (TBG) gene.Biochim. Biophys. Acta 1216:446-454.
  • Hayashi Y., et al.,(1993), Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.Mol. Endocrinol. 7:1049-1060.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TBG Antibody Rabbit Polyclonal ELISA 50313-RP01
    Anti-TBG Antibody Rabbit Polyclonal ELISA,IHC-P 50313-RP02
    Anti-TBG Antibody Rabbit Monoclonal ELISA 50313-R001
    Anti-TBG Antibody Rabbit Polyclonal ELISA 10993-RP02
    Anti-TBG Antibody Mouse Monoclonal ELISA 10993-MM02
    Anti-TBG Antibody Rabbit Polyclonal ELISA 10993-RP01
    info info
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