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SerpinA7 / TBG Antibody, Rabbit PAb, Antigen Affinity Purified

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    Human SerpinA7/TBG Antibody Product Information
    Immunogen:Recombinant Human SerpinA7 protein (Catalog#10993-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human SerpinA7 (rh SerpinA7; Catalog#10993-H08H; NP_000345.2; Met 1-Ala 415). SerpinA7 specific IgG was purified by human SerpinA7 affinity chromatography .
    Other SerpinA7/TBG Antibody Products
    SerpinA7 Background

    Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to the serpin family. TBG is synthesized primarily in the liver as a 54 kDa protein.TBG is genomically a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.

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