Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
- Human SerpinA6 Protein, Recombinant, Cat NO:10998-H08H
- Mouse SerpinA6 Protein, Recombinant, Cat NO:50314-M08H
- Anti-Human SerpinA6 Antibody, Rabbit PAb, Cat NO:10998-RP02
- Anti-Mouse SerpinA6 Antibody, Rabbit PAb, Cat NO:50314-RP02
SerpinA6 ELISA Pair sets
SerpinA6 cDNA Clones
- Homo sapiens SerpinA6 cDNA Clone, Cat NO:HG10998-M
- Mus musculus SerpinA6 cDNA Clone, Cat NO:MG50314-M
SerpinA6, CBG, corticosteroid binding globulin [Homo sapiens]
Serpina6, AI265318, AV104445, Cbg, corticosteroid binding globulin [Mus musculus]
Entrez Gene summary for SerpinA6:
SerpinA6 gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. SerpinA6 gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Wikipedia summary for SerpinA6:
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is an alpha-globulin.
Belongs to the serpin family.
N-glycosylated; binds 5 oligosaccharide chains.
Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
|Involvement in disease:||Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) . CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.|
General information above from UniProt
SerpinA6 is major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
- SerpinA6 is corticosteroid binding globulin
- SerpinA6 is serine proteinase inhibitor
- SerpinA6 is involved in the regulation of gene activity and chromatin structure
|CBG, SERPINA6||Corticosteroid-binding globulin deficiency|
Phenotype Information for SerpinA6 from OMIM (Online Mendelian Inheritance in Man)
|Target||Drug Name||Disease||Drug Status|
|SerpinA6||Beclomethasone||Asthma and allergic rhinitis||Approved|
|SerpinA6||Prednisolone||Asthma and rheumatoid arthritis||Approved|
|SerpinA6||Ciclesonide||Obstructive airway diseases||Approved|
|SerpinA6||Fluocinolone Acetonide||Inflammatory diseases||Approved|
|SerpinA6||Flumethasone Pivalate||Contact dermatitis||Approved|
Drugs for SerpinA6 from TTD (Therapeutic Targets Database)