SerpinA6 Protein & Antibody

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

SerpinA6 Products

SerpinA6 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
SerpinA6	Human	SerpinA6 Protein, Recombinant	10998-H08H
SerpinA6	Mouse	SerpinA6 Protein, Recombinant	50314-M08H

SerpinA6 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human SerpinA6	WB, ELISA	SerpinA6 Antibody, Rabbit PAb	10998-RP02
Human SerpinA6	ELISA	SerpinA6 Antibody	10998-R037
Mouse SerpinA6	WB, ELISA	SerpinA6 Antibody, Rabbit PAb	50314-RP02

SerpinA6 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
SerpinA6	Human	Homo sapiens SerpinA6 cDNA Clone	HG10998-M
SerpinA6	Mouse	Mus musculus SerpinA6 cDNA Clone	MG50314-M

SerpinA6 Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinA6

SerpinA6 Alternative Names

SerpinA6, CBG, corticosteroid binding globulin [Homo sapiens]

Serpina6, AI265318, AV104445, Cbg, corticosteroid binding globulin [Mus musculus]

SerpinA6 Background

Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.

SerpinA6 Related Studies

1. Seralini GE. (1991) A new role for corticosteroid binding globulin (CBG), member of SERPIN superfamily. C R Seances Soc Biol Fil. 185(6): 500-9.
2. Buss C, et al. (2007) Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency. J Neural Transm. 114(5): 563-9.
3. Torpy DJ, et al. (2007) Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 67(2): 161-7.
4. Braun BC, et al. (2010) Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity. J Steroid Biochem Mol Biol. 120(1): 30-7.
5. Lin HY, et al. (2010) Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol. 316(1): 3-12.