- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
SerpinA6 Antibody Datasheet
|Order or Inquire for SerpinA6 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.00975 ng/well in ELISA|
SerpinA6 Antibody Product Information
Recombinant Human SerpinA6 protein (Catalog#10998-H08H)
|Antibody Type :||Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.|
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA6 (rh SerpinA6; Catalog#10998-H08H; NP_001747.2; Met 1-Val 405).
SerpinA6 Antibody Usage Guide
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SerpinA6. The detection limit for Human SerpinA6 is approximately 0.00975 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
SerpinA6 Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|SerpinA6||Human||SerpinA6 Protein, Recombinant||10998-H08H|
|SerpinA6||Mouse||SerpinA6 Protein, Recombinant||50314-M08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||SerpinA6 Antibody, Rabbit PAb||10998-RP02|
|WB, ELISA||SerpinA6 Antibody, Rabbit PAb||50314-RP02|
SerpinA6 Antibody Background
The serpin peptidase inhibitor, clade A, member 6 (SerpinA6), also known as corticosteroid-binding globulin or CBG, is a member of Serpin (Serine Protease Inhibitors) superfamily. The superfamily of serine protease inhibitors (SERPINs) plays a key role in controlling the activity of proteinases in diverse biological processes. SerpinA6 is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and SerpinA6, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to SerpinA6 in human plasma). In this context, SerpinA6 directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. As a specific high-affinity plasma transport glycoprotein for cortisol. Stress-induced falls in CBG levels may heighten hypothalamic-pituitary-adrenal axis responses and CBG. The tissue interactions may allow targeted cortisol delivery. Three genetic variants of CBG have been identified that reduce cortisol binding affinity and/or CBG levels. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. SerpinA6/CBG is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates, and may involved in obesity and stress sensitivity.
- Gagliardi L. et al., 2010, Mol Cell Endocrinol.316 (1): 24-34.
- Seralini GE. 1991, C R Seances Soc Biol Fil. 185 (6): 500-9.
- Seixas S. et al., 2007, Mol Biol Evol. 24 (2): 587-98.
- Buss C. et al., 2007, J Neural Transm. 114 (5): 563-9.