Anti-alpha 1 Antichymotrypsin Antibody

Cat: 10307-RP01
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Anti-alpha 1 Antichymotrypsin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-alpha 1 Antichymotrypsin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human alpha 1 Antichymotrypsin
Immunogen
Recombinant Human SerpinA3 protein (Catalog#10307-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SerpinA3 (rh SerpinA3; Catalog#10307-H08H; NP_001076.2; Met 1-Ala 423). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-alpha 1 Antichymotrypsin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-alpha 1 Antichymotrypsin Antibody Alternative Names
Anti-AACT Antibody;Anti-ACT Antibody;Anti-GIG24 Antibody;Anti-GIG25 Antibody;Anti-MGC88254 Antibody;Anti-SERPINA3 Antibody
alpha 1 Antichymotrypsin Background Information

SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. In addition, ACT gene polymorphism has been implicated with Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.

Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
References
  • Nilsson, L.N. et al., 2001, J. Neurosci. 21: 1444-1451.
  • Ikari, Y. et al., 2001, J. Biol. Chem. 276: 11798-11803.
  • Vila, N. et al., 2000, Stroke. 31: 2103-2105
  • Eriksson, S. et al., 1995, Proc. Natl. Acad. Sci. USA. 92: 2313-2317.
  • Skeel, A. et al., 2001, J. Biol. Chem. 276: 21932-21937.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-alpha 1 Antichymotrypsin Antibody Rabbit Monoclonal ELISA(Cap) 10307-R011
    Anti-alpha 1 Antichymotrypsin Antibody Mouse Monoclonal ELISA 10307-MM05
    Anti-alpha 1 Antichymotrypsin Antibody Rabbit Polyclonal WB,ELISA 10307-RP02
    Anti-alpha 1 Antichymotrypsin Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10307-R006
    Anti-alpha 1 Antichymotrypsin Antibody Rabbit Polyclonal ELISA 10307-T16
    Anti-alpha 1 Antichymotrypsin Antibody Mouse Monoclonal ELISA 10307-MM04
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