alpha 1 Antitrypsin (Protein|Antibody|cDNA Clone|ELISA Kit)

All alpha 1 Antitrypsin reagents are produced in house and quality controlled, including 10 alpha 1 Antitrypsin Antibody, 2 alpha 1 Antitrypsin ELISA, 39 alpha 1 Antitrypsin Gene, 2 alpha 1 Antitrypsin Lysate, 2 alpha 1 Antitrypsin Protein, 2 alpha 1 Antitrypsin qPCR. All alpha 1 Antitrypsin reagents are ready to use.

Recombinant alpha 1 Antitrypsin proteins are expressed by HEK293 Cells with fusion tags as C-His.

alpha 1 Antitrypsinantibodies are validated with different applications, which are ELISA(Cap), ELISA, WB, IP, ELISA(Det).

alpha 1 AntitrypsincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each alpha 1 Antitrypsin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

alpha 1 AntitrypsinELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

alpha 1 Antitrypsin Protein (2)

Species

alpha 1 Antitrypsin Protein, Rat, Recombinant (His Tag)

80476-R08H

Expression host: HEK293 Cells

Rat SerpinA1 Protein 12662

alpha 1 Antitrypsin Protein, Human, Recombinant (His Tag)

10306-H08H

Expression host: HEK293 Cells

Human SerpinA1 Protein 8650
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alpha 1 Antitrypsin Antibody (10)

Application Clonality
Host

Anti-alpha 1 Antitrypsin Antibody

10306-R204

Application: ELISA

Clonality: MAb

Anti-alpha 1 Antitrypsin Antibody

80476-T36

Application: WB,IP

Clonality: PAb

Anti-alpha 1 Antitrypsin Antibody

10306-RP02

Application: ELISA

Clonality: PAb

Anti-alpha 1 Antitrypsin Antibody

80476-T52

Application: WB,ELISA,IP

Clonality: PAb

Anti-alpha 1 Antitrypsin Antibody

10306-R142

Application: ELISA(Cap)

Clonality: MAb

Anti-alpha 1 Antitrypsin Antibody

10306-RP01

Application: WB,ELISA

Clonality: PAb

Human SerpinA1 Western blot (WB) 13177

Anti-alpha 1 Antitrypsin Antibody

80476-RP01

Application: ELISA

Clonality: PAb

Anti-alpha 1 Antitrypsin Antibody

80476-T16

Application: ELISA

Clonality: PAb

Anti-alpha 1 Antitrypsin Antibody

80476-R005

Application: ELISA

Clonality: MAb

Anti-alpha 1 Antitrypsin Antibody

10306-R005

Application: ELISA(Det)

Clonality: MAb

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alpha 1 Antitrypsin ELISA KIT & match antibody elias pair set ( 2 )

alpha 1 Antitrypsin ELISA Kit, Human

KIT10306

Sensitivity: 26.37 pg/mL

Human SerpinA1 ELISA Kit Standard Curve 17209

alpha 1 Antitrypsin cDNA Clone (39)

Human
Rat

alpha 1 Antitrypsin qPCR Primer (2)

alpha 1 Antitrypsin Lysate (2)

SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. It association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and a complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes.

Protein
Antibody
ELISA
Gene
qPCR
Lysate
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