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> SerpinA1 Protein, Antibody, ELISA Kit, cDNA Clone SerpinA1 Protein, Antibody, ELISA Kit, cDNA Clone
SerpinA1 Protein, Antibody, ELISA Kit, cDNA Clone Products
With multiple advanced technology platforms and large scale capacities, Sino Biological has quickly emerging as a leader of life science research tool developer worldwide. All our proteins are manufactured in bulk quantities using sequence verified vectors and state-of-the-art mammalian, insect, or E. coli expression processes. We are adding more than 800 proteins per year, of which "hot" proteins are high on the priority list, such as H1N1 antigens and antibodies that we offered.
Sino Biological Inc offers quality SerpinA1 Protein, Antibody, ELISA Kit, cDNA Clone Products for research .
Browse SerpinA1 Protein, Antibody, ELISA Kit, cDNA Clone Products by following categories
SerpinA1 Protein, Antibody, ELISA Kit, cDNA Clone
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SerpinA1 Protein
– Human SerpinA1 Protein
– Mouse SerpinA1 Protein
– Rat SerpinA1 Protein
– Rhesus SerpinA1 Protein
– Cynomolgus SerpinA1 Protein
– Canine (Dog) SerpinA1 Protein
– Ferret SerpinA1 Protein
– Bovine SerpinA1 Protein
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SerpinA1 Antibody
– Human SerpinA1 Antibody
– Mouse SerpinA1 Antibody
– Rat SerpinA1 Antibody
– Rhesus SerpinA1 Antibody
– Cynomolgus SerpinA1 Antibody
– Canine (Dog) SerpinA1 Antibody
– Ferret SerpinA1 Antibody
– Bovine SerpinA1 Antibody
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SerpinA1 ELISA Kit
– Human SerpinA1 ELISA Kit
– Mouse SerpinA1 ELISA Kit
– Rat SerpinA1 ELISA Kit
– Rhesus SerpinA1 ELISA Kit
– Cynomolgus SerpinA1 ELISA Kit
– Canine (Dog) SerpinA1 ELISA Kit
– Ferret SerpinA1 ELISA Kit
– Bovine SerpinA1 ELISA Kit
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SerpinA1 cDNA Clone
– Human SerpinA1 cDNA Clone
– Mouse SerpinA1 cDNA Clone
– Rat SerpinA1 cDNA Clone
– Rhesus SerpinA1 cDNA Clone
– Cynomolgus SerpinA1 cDNA Clone
– Canine (Dog) SerpinA1 cDNA Clone
– Ferret SerpinA1 cDNA Clone
– Bovine SerpinA1 cDNA Clone
Antibody to SerpinA1
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ELISA Antibody to SerpinA1
– ELISA Antibody to Human SerpinA1
– ELISA Antibody to Mouse SerpinA1
– ELISA Antibody to Rat SerpinA1
– ELISA Antibody to Rhesus SerpinA1
– ELISA Antibody to Cynomolgus SerpinA1
– ELISA Antibody to Canine (Dog) SerpinA1
– ELISA Antibody to Ferret SerpinA1
– ELISA Antibody to Bovine SerpinA1
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Western Blot Antibody to SerpinA1
– Western Blot Antibody to Human SerpinA1
– Western Blot Antibody to Mouse SerpinA1
– Western Blot Antibody to Rat SerpinA1
– Western Blot Antibody to Rhesus SerpinA1
– Western Blot Antibody to Cynomolgus SerpinA1
– Western Blot Antibody to Canine (Dog) SerpinA1
– Western Blot Antibody to Ferret SerpinA1
– Western Blot Antibody to Bovine SerpinA1
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Immunohistochemistry (IHC) Antibody to SerpinA1
– Immunohistochemistry (IHC) Antibody to Human SerpinA1
– Immunohistochemistry (IHC) Antibody to Mouse SerpinA1
– Immunohistochemistry (IHC) Antibody to Rat SerpinA1
– Immunohistochemistry (IHC) Antibody to Rhesus SerpinA1
– Immunohistochemistry (IHC) Antibody to Cynomolgus SerpinA1
– Immunohistochemistry (IHC) Antibody to Canine (Dog) SerpinA1
– Immunohistochemistry (IHC) Antibody to Ferret SerpinA1
– Immunohistochemistry (IHC) Antibody to Bovine SerpinA1
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Flow Cytometry (FACS) Antibody to SerpinA1
– Flow Cytometry (FACS) Antibody to Human SerpinA1
– Flow Cytometry (FACS) Antibody to Mouse SerpinA1
– Flow Cytometry (FACS) Antibody to Rat SerpinA1
– Flow Cytometry (FACS) Antibody to Rhesus SerpinA1
– Flow Cytometry (FACS) Antibody to Cynomolgus SerpinA1
– Flow Cytometry (FACS) Antibody to Canine (Dog) SerpinA1
– Flow Cytometry (FACS) Antibody to Ferret SerpinA1
– Flow Cytometry (FACS) Antibody to Bovine SerpinA1
SerpinA1 Products
All SerpinA1 Products list
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SerpinA1 Protein
SerpinA1 Protein, Recombinant 10306-H08H -
SerpinA1 Antibody
SerpinA1 Antibody 10306-RP01 SerpinA1 Antibody (Antigen Affinity Purified) 10306-RP02 -
SerpinA1 ELISA Kit
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SerpinA1 cDNA Clone
Homo sapiens SerpinA1 transcript variant 1 cDNA Clone(NM_000295.4) HG10306-M
Summary of SerpinA1 Protein, Antibody, ELISA Kit, cDNA Clone
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. It association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and a complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes.
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