Semaphorin 6A (SEMA6A)

Semaphorin 6A is cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Semaphorin 6A is required for normal granule cell migration in the developing cerebellum. Semaphorin 6A promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Semaphorin 6A can act as repulsive axon guidance cue. Semaphorin 6A has repulsive action towards migrating granular neurons. Semaphorin 6A may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.

Semaphorin 6A (SEMA6A) Related Areas

Neuroscience>>Axon Guidance>>Semaphorin & Related Molecules>>Semaphorin 6A/SEMA6A

Semaphorin 6A (SEMA6A) Alternative Names

Semaphorin 6A , SEMA6A, HT018, KIAA1368, SEMA, SEMA6A1, SEMAQ, VIA [Homo sapiens]

Semaphorin 6A, Sema6a, 9330158E07, A730020P05Rik, AI851735, Sema6A-1, Semaq, VIa [Mus musculus]

Summaries for Semaphorin 6A (SEMA6A)

Entrez Gene summary for Semaphorin 6A (SEMA6A):

The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

OMIM - description for Semaphorin 6A (SEMA6A):

The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001).

Wikipedia summary for Semaphorin 6A (SEMA6A):

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.
In melanocytic cells SEMA6A gene expression may be regulated by MITF.

Human Semaphorin 6A (SEMA6A) Protein General Information

 

• Protein names: Semaphorin-6A
  Short name=SEMA6A
• Sequence length: 1030 AA.
• Domain: Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Belongs to the semaphorin family.
  Contains 1 PSI domain.
  Contains 1 Sema domain.
• Sequence caution: The sequence BAA92606.1 differs from that shown. Reason: Erroneous initiation.
• Subunit structure: Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer By similarity. Interacts with EVL.
• Subcellular location: Cell membrane; Single-pass type I membrane protein.

General information above from UniProt

Function for Semaphorin 6A (SEMA6A) Protein

UniProtKB:

Semaphorin 6A is cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Semaphorin 6A is required for normal granule cell migration in the developing cerebellum. Semaphorin 6A promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Semaphorin 6A can act as repulsive axon guidance cue. Semaphorin 6A has repulsive action towards migrating granular neurons. Semaphorin 6A may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.

Genatlas:

• SEMA6A is retrograde signaling
• SEMA6A has a novel function in the cytoskeleton and a playing a role in modulating tubulin isotype composition and microtubule dynamics

Homology for human Semaphorin 6A (SEMA6A)

• ortholog to murine Sema6a