Semaphorin 4A (SEMA4A, Semaphorin B)

Semaphorin 4A is cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Semaphorin 4A plays a role in priming antigen-specific T cells, promotes differentiation of Th1 T helper cells, and thereby contributes to adaptive immunity. Semaphorin 4A promotes phosphorylation of TIMD2. Semaphorin 4A inhibits angiogenesis. Semaphorin 4A promotes axon growth cone collapse. Semaphorin 4A inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Semaphorin 4A (SEMA4A, Semaphorin B) Related Areas

Neuroscience>>Axon Guidance>>Semaphorin & Related Molecules>>Semaphorin 4A/SEMA4A/Semaphorin B

Semaphorin 4A (SEMA4A, Semaphorin B) Alternative Names

Semaphorin 4A, SEMA4A, RP11-54H19.2, CORD10, FLJ12287, RP35, SEMAB, SEMB, sema B, semaphorin-4A, semaphorin-B [Homo sapiens]

Semaphorin 4A, Sema4a, AI132332, SemB, Semab, sema B, semaphorin-4A, semaphorin-B [Mus musculus]

Summaries for Semaphorin 4A (SEMA4A, Semaphorin B)

Entrez Gene summary for Semaphorin 4A (SEMA4A, Semaphorin B):

SEMA4A gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in SEMA4A gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

OMIM - description for Semaphorin 4A (SEMA4A, Semaphorin B):

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.

Wikipedia summary for Semaphorin 4A (SEMA4A, Semaphorin B):

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.
SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM]

Human Semaphorin 4A (SEMA4A, Semaphorin B) Protein General Information

 

• Protein names: Semaphorin-4A
  Short name=SEMA4A
• Sequence length: 761 AA.
• Domain: Immunoglobulin domain
  Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Belongs to the semaphorin family.
  Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  Contains 1 PSI domain.
  Contains 1 Sema domain.
• Subunit structure: Interacts with PLXNB1, PLXNB2, PLXNB3 and PLXND1. Probable ligand for TIMD2
• Subcellular location: Cell membrane; Single-pass type I membrane protein
• Involvement in disease: Defects in SEMA4A are the cause of retinitis pigmentosa type 35 (RP35) . RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  Defects in SEMA4A are the cause of cone-rod dystrophy type 10 (CORD10) . CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.

General information above from UniProt

Function for Semaphorin 4A (SEMA4A, Semaphorin B) Protein

UniProtKB:

Semaphorin 4A is cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Semaphorin 4A plays a role in priming antigen-specific T cells, promotes differentiation of Th1 T helper cells, and thereby contributes to adaptive immunity. Semaphorin 4A promotes phosphorylation of TIMD2. Semaphorin 4A inhibits angiogenesis. Semaphorin 4A promotes axon growth cone collapse. Semaphorin 4A inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Genatlas:

• Semaphorin 4A is inhibition of axonal extension by providing local signals to specify territories inaccessible for growing axons
• Semaphorin 4A is involved in the activation of T cells through interactions with TIM2
• Semaphorin 4A plays a crucial role for the differentiation of CD4+ T-cells
• Semaphorin 4A enhances T-cell activation
• Semaphorin 4A is critically involved in the development of myocarditis and dilated cardiomyopathy
• Semaphorin 4A seems to function in the reciprocal stimulation of T cells and antigen-presenting cells (APCs)

Phenotype Information for Semaphorin 4A (SEMA4A, Semaphorin B)

• Gene/Locus: SEMA4A, SEMB, RP35, CORD10
• Phenotype: Cone-rod dystrophy 10
  Retinitis pigmentosa 35

Phenotype Information for Semaphorin 4A (SEMA4A, Semaphorin B) from OMIM (Online Mendelian Inheritance in Man)