Selenoprotein M

Selenoprotein M is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine M is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures. Selenoprotein M May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. This protein is widely expressed and is highly expressed in brain. It is found in Cytoplasm, perinuclear region, Endoplasmic reticulum, Golgi apparatus. Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum. Experiments results have suggested that selenoprotein M may have an important role in protecting against oxidative damage in the brain and may potentially function in calcium regulation.

Selenoprotein M Alternative Names

1500040L08Rik, A230103K18, Sepm [Mus musculus]

Summaries for Selenoprotein M

Entrez Gene summary for Selenoprotein M:

SELM gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures. [provided by RefSeq, Jul 2008]

OMIM - description for Selenoprotein M:

Selenoproteins, such as SELM, contain a selenocysteine (sec) residue and a stem-loop structure sec insertion sequence (SECIS) element in the 3-prime untranslated region that is essential for recognition of UGA as a codon for sec rather than as a stop signal. The functional part of SECIS is composed of a helix containing non-Watson-Crick base pairs UGAN-NGAN, designated the quartet or core, and other elements, including an unpaired AA motif in the apical bulge (summary by Korotkov et al., 2002).

Human Selenoprotein M Protein General Information

 

• Protein names: Selenoprotein M
  Short name=SelM
• Sequence length: 145 AA.
• Domain: Signal
• Sequence similarities: Belongs to the selenoprotein M/SEP15 family.
• Subcellular location: Cytoplasm › perinuclear region. Endoplasmic reticulum . Golgi apparatus . Note: Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.
• Tissue specificity: Widely expressed.

General information above from UniProt

Function for Selenoprotein M Protein

UniProtKB:

Selenoprotein M may function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Genatlas:

• Selenoprotein M may function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation
• Selenoprotein M is thiol-disulfide oxidoreductases that may contribute to the quality control pathways of the endoplasmic reticulum

Homology for human Selenoprotein M

• ortholog to murine Sepm