Anti-Sclerostin Antibody

Cat: 10593-MM01
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Anti-Sclerostin Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Sclerostin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Sclerostin
Immunogen
Recombinant Human SOST protein ( Catalog#10593-H07H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SOST (rhSOST; Catalog#10593-H07H; NP_079513.1; Gln 24-Tyr 213). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #5D8D2D4
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Sclerostin Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Sclerostin Antibody Alternative Names
Anti-CDD Antibody;Anti-DAND6 Antibody;Anti-SOST1 Antibody;Anti-VBCH Antibody
Sclerostin Background Information

Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.

Full Name
sclerostin
References
  • Bellido T. (2006) Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes. J Musculoskelet Neuronal Interact. 6(4): 358-9.
  • van Bezooijen RL, et al. (2007) SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development. Dev Dyn. 236(2): 606-12.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Sclerostin Antibody Rabbit Polyclonal ELISA 80009-T16
    Anti-Sclerostin Antibody Rabbit Monoclonal ELISA 80009-R118
    Anti-Sclerostin Antibody Rabbit Polyclonal ELISA 80009-RP01
    Anti-Sclerostin Antibody Rabbit Polyclonal ELISA 10593-T16
    Anti-Sclerostin Antibody Rabbit Polyclonal ELISA 10593-RP02
    Anti-Sclerostin Antibody Rabbit Polyclonal ELISA 10593-RP04
    Anti-Sclerostin Antibody Rabbit Monoclonal ELISA 10593-RM03
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