Scavenger Receptor

Sino biological offers a comprehensive set of tools for scavenger receptor related research, including:

Product Categories / Species	Human	Mouse
Recombinant Proteins	9	11
Antibodies	13	13
ELISA Kit	1	-
ORF cDNA Clones	10	12

Scavenger Receptor Products

• CD5
• CL-K1 / COLEC11
• LOX-1
• CD5L
• CL-P1 / COLEC12
• MARCO
• CD36 / SR-B3
• DMBT1 / Muclin
• MSR1 / CD204
• CD68
• LDL Receptor
• SCARB1 / CD36L1 / SR-B1
• CD163
• LIMP-2 / SCARB2 / CD36L2

Scavenger Receptor Background

Scavenger receptors were discovered as cell surface proteins that can bind and internalize modified low-density lipoproteins (LDL. See lipid metabolism). Scavenger receptors were initially described in cultured macrophages in which they mediate cholesterol uptake from modified lipoproteins determining the formation of lipid loaded macrophages closely resembling the foam cells present in atherosclerotic lesions. In fact, scavenger receptors are also expressed by dendritic cells and endothelial cells, and they exhibit a broad ligand binding specificity including potential physiological and pathophysiological ligands other than modified lipoproteins. They play an important role in uptake and clearance of effete components, such as modified host molecules and apoptotic cells.

Based on their structural characteristics, scavenger receptors can be categorized into classes A, B, and C. The class A scavenger receptors (SR-A1 and SR-A2) have a collagen-like domain, which is essential for ligand binding. SR-A1 and SR-A2 are generated by alternative splicing; SR-A1 has an additional carboxi-terminal cysteine-rich domain, which is not present in SR-A 2. Another structurally related scavenger receptor, MARCO (macrophage receptor with collagenous structure), has collagen-like and cysteine-rich domains. class B scavenger receptors have two transmembrane regions and class C scavenger receptors have extracellular N-terminal domain.

Scavenger Receptor Related Studies

1. Suzuki H, et al. (1997) A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature. 386(6622):292-6.
2. Peiser L, et al. (2002) Scavenger receptors in innate immunity. Curr Opin Immunol. 14(1):123-8.
3. Silverstein RL, et al. (2009) CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Sci Signal. 2(72):re3.
4. Saddar S, et al. (2010) Signaling by the high-affinity HDL receptor scavenger receptor B type I. Arterioscler Thromb Vasc Biol. 30(2):144-50.