SUV420H2

SUV420H2 is histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV420H2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2)

SUV420H2 Related Areas

Enzyme>>Methyltransferase>>SUV420H2

SUV420H2 Alternative Names

SUV420H2, PP7130, FLJ98627, KMT5C, MGC2705 [Homo sapiens]

Suv420h2, BC024816, KMT5C, MGC36471, Suv4-20h2 [Mus musculus]

Summaries for SUV420H2

Entrez Gene summary for SUV420H2:

SUV420H2 and the related enzyme SUV420H1 function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 on lysine-20 (K20) (Schotta et al., 2004 ).[supplied by OMIM, Dec 2009]

OMIM - description for SUV420H2:

SUV420H2 and the related enzyme SUV420H1 function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 on lysine-20 (K20) (Schotta et al., 2004).

Human SUV420H2 Protein General Information

 

• Protein names: Histone-lysine N-methyltransferase SUV420H2
  Short name=SUV420H2
• Sequence length: 462 AA.
• Sequence similarities: Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily.
  Contains 1 SET domain.
• Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
• Subunit structure: Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2
• Subcellular location: Nucleus. Chromosome . Note: Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin .

General information above from UniProt

Function for SUV420H2 Protein

UniProtKB:

SUV420H2 is histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV420H2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2)

Genatlas:

• SUV420H2 histone methyltransferases activity (Schotta 2004)
• SUV420H2 may be recruited to heterochromatin in association with CBX1, CBX3, CBX5, and stably maintained at its heterochromatin sites in an CBX-independent fashion (Souza 2009)