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>SUMO-1 / SUMO1 Protein & Antibody
SUMO-1 / SUMO1 Protein & Antibody
Small ubiquitin-related modifier 1
SUMO-1 Protein, Recombinant
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|SUMO-1||Human||SUMO1/SUMO-1 Protein, Recombinant||13095-H07E|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human SUMO-1||WB, ELISA||SUMO1 / SUMO-1 Antibody||13095-RP01|
|Human SUMO-1||WB, ELISA||SUMO1 / SUMO-1 Antibody (Antigen Affinity Purified)||13095-RP02|
SUMO-1 Alternative Names
SUMO-1, SUMO1, OK/SW-cl.43, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1 [Homo sapiens]
SUMO-1, Sumo1, GMP1, MGC103203, PIC1, SENTRIN, SMT3, SMT3H3, SMTP3, Smt3C, Ubl1 [Mus musculus]
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2.
SUMO-1 Related Studies
- Kim HJ, et al. (2011) SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2. Biochem Biophys Res Commun. 410(3): 555-62.
- Zuo Y, et al. (2009) Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer. Asian J Androl. 11(1): 36-8.
- Song T, et al. (2008) SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate. Biochem Biophys Res Commun. 377(4): 1265-8.
- Katayama A, et al. (2007) Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis. Int J Oncol. 31(3): 517-24.