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SUMO-1 / SUMO1 Protein & Antibody

Small ubiquitin-related modifier 1

SUMO-1 Products

SUMO-1 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
SUMO-1 Human SUMO1/SUMO-1 Protein, Recombinant 13095-H07E

SUMO-1 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human SUMO-1 WB, ELISA SUMO1 / SUMO-1 Antibody 13095-RP01
Human SUMO-1 WB, ELISA SUMO1 / SUMO-1 Antibody (Antigen Affinity Purified) 13095-RP02

SUMO-1 Alternative Names

SUMO-1, SUMO1, OK/SW-cl.43, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1 [Homo sapiens]

SUMO-1, Sumo1, GMP1, MGC103203, PIC1, SENTRIN, SMT3, SMT3H3, SMTP3, Smt3C, Ubl1 [Mus musculus]

SUMO-1 Background

Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2.

SUMO-1 Related Studies

  1. Kim HJ, et al. (2011) SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2. Biochem Biophys Res Commun. 410(3): 555-62.
  2. Zuo Y, et al. (2009) Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer. Asian J Androl. 11(1): 36-8.
  3. Song T, et al. (2008) SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate. Biochem Biophys Res Commun. 377(4): 1265-8.
  4. Katayama A, et al. (2007) Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis. Int J Oncol. 31(3): 517-24.



SUMO-1 / SUMO1 related areas, pathways, and other information