SULT2A1

SULT2A1 is sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

SULT2A1 Related Areas

Enzyme>>Sulfatase & Sulfotransferase>>SULT2A1

SULT2A1 Alternative Names

SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa [Homo sapiens]

Sult2a1, ST2A1, Std, Sth1, mSTa1 [Mus musculus]

Summaries for SULT2A1

Entrez Gene summary for SULT2A1:

SULT2A1 gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

OMIM - description for SULT2A1:

The SULT2A1 gene encodes dehydroepiandrosterone sulfotransferase (DHEAST), which catalyzes the 3-prime-phosphoadenosine 5-prime-phosphosulfate-dependent sulfation of a wide variety of steroids in human liver and adrenal tissue and is responsible for sulfation of bile acids in human liver (summary by Comer et al., 1993).

Wikipedia summary for SULT2A1:

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

Human SULT2A1 Protein General Information

 

• Protein names: Sulfotransferase 2A1
  Short name=SULT2A1
• Sequence length: 285 AA.
• Miscellaneous: Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta.
• Sequence similarities: Belongs to the sulfotransferase 1 family.
• Post-translational modification: The N-terminus is blocked.
• Subunit structure: Homodimer.
• Subcellular location: Cytoplasm.
• Tissue specificity: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.
• Catalytic activity: 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
  3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

General information above from UniProt

Function for SULT2A1 Protein

UniProtKB:

SULT2A1 is sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

Genatlas:

• SULT2A1 is sulfotransferase, a major adrenal steroid, precursor for androgen and estrogen biosynthesis in peripheral tissues
• SULT2A1 catalyzes the formation of DHEA-S
• SULT2A1 is involved in the fine control of target cell sensitivity to hormone action
• SULT2A1 plays a potential role in the inherited adrenal androgen excess of polycystic ovary syndrome

Homology for human SULT2A1

• homolog to murine Sult2a1