SULT1B1

SULT1B1 is sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. SULT1B1 sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.

SULT1B1 Related Areas

Enzyme>>Sulfatase & Sulfotransferase>>SULT1B1

SULT1B1 Alternative Names

SULT1B1, ST1B1, MGC13356, ST1B2, SULT1B2 [Homo sapiens]

Sult1b1, ST1B1 [Mus musculus]

Summaries for SULT1B1

Entrez Gene summary for SULT1B1:

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]

OMIM - description for SULT1B1:

Sulfotransferases catalyze the biotransformation of a large number of endogenous compounds such as neurotransmitters, steroids, bile acids, and thyroid hormones, as well as drugs and xenobiotics. SULT1B was originally identified as a thyroid hormone sulfotransferase but it also conjugates other phenols and is effective in the activation of certain benzylic alcohols derived from polycyclic hydrocarbon to mutagens (summary by Wang et al., 1998 and Meinl and Glatt, 2001).

Wikipedia summary for SULT1B1:

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes.

Human SULT1B1 Protein General Information

 

• Protein names: Sulfotransferase family cytosolic 1B member 1
  Short name=SULT1B1
• Sequence length: 296 AA.
• Sequence similarities: Belongs to the sulfotransferase 1 family.
• Subunit structure: Monomer
• Subcellular location: Cytoplasm
• Tissue specificity: Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.

General information above from UniProt

Function for SULT1B1 Protein

UniProtKB:

SULT1B1 is sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. SULT1B1 sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.

Genatlas:

• SULT1B1 catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds

Homology for human SULT1B1

• homolog to murine Sult1d1
• homolog to SULT1