SULT1A3 Protein

Sulfotransferase 1A3/1A4

SULT1A3 Products

SULT1A3 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
SULT1A3	Human	SULT1A3 Protein, Recombinant (His Tag)	11408-H07E

SULT1A3 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
SULT1A3	Human	Human SULT1A3 Gene cDNA Clone / ORF Clone	HG11408-M

SULT1A3 Related Areas

Enzyme>>Other>> SULT1A3

SULT1A3 Alternative Names

HAST, HAST3, M-PST, MGC117469, ST1A3/ST1A4, ST1A5, STM, TL-PST, aryl sulfotransferase 1A3/1A4, catecholamine-sulfating phenol sulfotransferase, dopamine-specific sulfotransferase, monoamine-sulfating phenosulfotransferase, phenol sulfotransferase 1A5, placental estrogen sulfotransferase, sulfokinase, sulfotransferase 1A3/1A4, thermolabile (monoamine, M form) phenol sulfotransferase [Homo sapiens]

SULT1A3 Background

SULT1A3 belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are different in their tissue distributions and substrate specificities while their gene structure (number and length of exons) is similar. SULT1A3 gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. It is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). SULT1A3 is expressed in liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte. SULT1A3 is a sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

SULT1A3 Related Studies

1. Dajani R, et al. (1999) Kinetic properties of human dopamine sulfotransferase (SULT1A3) expressed in prokaryotic and eukaryotic systems: comparison with the recombinant enzyme purified from Escherichia coli. Protein Expr. Purif. 16 (1): 11-8.
2. Dajani R, et al. (2000) X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. J. Biol. Chem. 274 (53): 37862-8.
3. Yasuda S, et al. (2011) Sulfation of chlorotyrosine and nitrotyrosine by human lung endothelial and epithelial cells: role of the human SULT1A3. Toxicol Appl Pharmacol. 251 (2): 104-9.
4. Hildebrandt MA, et al. (2004) Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. Biochem Biophys Res Commun. 321 (4): 870-8.
5. Lu JH, et al. (2005) Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 335 (2): 417-23.